Results 31 to 40 of about 8,430 (252)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Baštinska građa Župe sv. Mihaela Arkanđela u osječkoj Tvrđi: ishodište kulturnoga pamćenja grada

Diacovensia, 2019
The identity of Tvrđa (Fortress) consists of memory collections of cultural and historical identities preserved in heritage institutions. The work of heritage institutions in the area of public memory is to embody spatial and symbolic engagement of an ...
Hrvoje Mesić
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

To apply or not to apply? That is the question. Descriptors of the National Library as a proposal of changes in the development of sets in the opinion of the libraries of Higher Vocational Schools in Poland

Rozprawy Społeczne, 2019
Introduction. The aim of this article is to present the opinion of catalogue specialists working in state libraries of Higher Vocational Schools (HVS) in Poland about descriptors of the National Library (dNL), presentation of data relating to the ...
Katarzyna Cyran, Cezary Borkowicz, Wojciech Kowalewski   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

DESCRIPTIVE CATALOGUING IN SCIENTIFIC LIBRARY OF THE ODESSA I. I. MECHNIKOV NATIONAL UNIVERSITY: THEORY, HISTORY AND METHODS

Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Bìblìotekoznavstvo, Bìblìografoznavstvo, Knigoznavstvo, 2017
The article describes one of the main traditional processes librarianship of Scientific Library of the Odessa National I. I. Mechnikov University – descriptive cataloging.
Н. Е. Данилюк
doaj  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Se il catalogo parlasse, lo capiremmo? Cinque assiomi della comunicazione catalografica

AIB Studi, 2017
L’articolo cerca di applicare i criteri usati nell’analisi della comunicazione alla ‘comunicazione catalografica’, ossia allo scambio consapevole e inconsapevole di informazioni che avviene tra un catalogo e un utente durante l’intera fase di ricerca. La
Agnese Galeffi
doaj   +1 more source