Results 161 to 170 of about 55,942 (295)

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Proteoform medicine: characterizing and targeting protein forms in human disease. [PDF]

Nat Rev Genet
Korchak JA, Stephen Yi S, Kelleher NL, Sahni N, Sheynkman GM.   +4 more
europepmc   +1 more source

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

Annual Report for the Year 1999-2000 [PDF]

, 2000
Cambridge University Library
core  

Diagnostic Blood-Based Biomarkers of Amyloid-β and Tau Pathologies Prior to Alzheimer's Disease Diagnosis: a Rapid Umbrella Review. [PDF]

SN Compr Clin Med
Yousefzadeh N, Sharma O, Oliver A, O'Keefe H, Robertson EG, Harris B, Spiers GF, Craig D.   +7 more
europepmc   +1 more source

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

Catalogue of standard seeds /

, 1895
openaire   +2 more sources

Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants. [PDF]

Sci Adv
Berman P, Höfer J, Mehlman H, Almekias-Siegl E, Khersonsky O, Dong Y, Heinig U, Sulimani L, Hao LK, Cohen S, Peleg Y, Meir S, Rogachev I, Meiri D, Fleishman SJ, Aharoni A.   +15 more
europepmc   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Comprehensive dataset of Portuguese folk instruments for computer vision and heritage research. [PDF]

Data Brief
Silva Zendron LA, Sánchez San Blas H, Sales Mendes AF, Jiménez-Bravo DM, Lozano Murciego Á.   +4 more
europepmc   +1 more source