Results 191 to 200 of about 55,736 (295)

D5 digital circular workflow: five digital steps towards matchmaking for material reuse in construction. [PDF]

Npj Mater Sustain
De Wolf C, Byers BS, Raghu D, Gordon M, Schwarzkopf V, Triantafyllidis E.   +5 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Algor-Ethics in Diabetes Care: Mapping the Route. [PDF]

Diabetes Metab Res Rev
Bemporad J, De Domenico F, Pozzilli P.
europepmc   +1 more source

A “Hot Spring” Mimetic Aerogel Loaded with Multiple Amino Acids Modulates the Chronic Inflammatory Microenvironment Through Metabolic Reprogramming

Advanced Science, EarlyView.
The SrCuSi4O₁₀ bioceramic particles mimic the effects of hot spring therapy by increasing the local wound temperature, which enhances the absorption of amino acids and stimulates cell metabolism. The amino acid uptake supports cellular glutathione redox reactions, helping to mitigate oxidative stress.
Bo Li, Dandan Jin, Fei Li, Jianliang Shen, Jiang Chang, Chen Yang, Shixuan Chen, Yi Zhang   +7 more
wiley   +1 more source

A global biodiversity use data infrastructure acknowledging indigenous and local knowledge. [PDF]

NPJ Biodivers
Pankararu CJ, Teixidor-Toneu I, Odonne G, Asante F, Bandeira SO, Barrera-Bello ÁM, Benitez-Capistros FJ, Dahdouh-Guebas F, Dalcin E, Dennehy-Carr ZH, Diallo K, Drouet-Cruz HT, Fonseca-Kruel VS, Gallois S, Gnansounou SC, Hamza AJ, Hugé J, Jordan FM, Kalle R, Khan NI, Kuijper I, Levis C, Lima AS, Mattalia G, Milliken W, Munga CN, Narchi NE, Ngeve MN, Ofori SA, Phartyal SS, Peroni N, Pironon S, Polanía J, Prakofjewa J, Silva MT, Sõukand R, Thomas MB, Ulian T, Uprety Y, Vandebroek I, Ximenes AC, Zank S, Hanazaki N.   +42 more
europepmc   +1 more source

Forecasting Root Rot Disease through Predictive Microbial Functional Profiling

Advanced Science, EarlyView.
Predicting soil‐borne disease moves beyond observation with a framework that elevates microbial functional genes into reliable forecasting biomarkers. By coupling targeted qPCR assays for core stress‐response genes with machine learning, this method detects root rot risks in pre‐symptomatic soils with over 80% accuracy.
Chuan You, Peng Ren, Ying Guan, Kai Gong, Zhen Hua, Wuxian Zhou, Xinlan Mei, Yikui Wang, Xiaofang Wang, Yangchun Xu, Qirong Shen, Zhong Wei   +11 more
wiley   +1 more source

Misidentified cell lines: failures of peer review, varying journal responses to misidentification inquiries, and strategies for safeguarding biomedical research. [PDF]

Res Integr Peer Rev
Weiskirchen R.
europepmc   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

Review: Compliance standards for dairy cattle welfare in European countries. [PDF]

Vet Anim Sci
Debertolis L, Holighaus L, Gauly M, Zanon T.   +3 more
europepmc   +1 more source