Results 71 to 80 of about 7,177,384 (298)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Preparation and Characterization of NiMo/Al2O3Catalyst for Hydrocracking Processing
E3S Web of Conferences, 2018 Hydrocracking is a chemical process used in petroleum refineries for converting high boiling hydrocarbons in petroleum crude oils to more valuable lower boiling products such as gasoline, kerosene, and diesel oil that operate at high temperature and ...
Widiyadi Aditya +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
PUDL Raw EPA Hourly Continuous Emission Monitoring System (CEMS)
, 2023 <p>US EPA hourly Continuous Emissions Monitoring System (CEMS) data. Hourly CO2, SO2, NOx emissions and gross load. Archived from <a href="https://campd.epa.gov/">https://campd.epa.gov/</a></p><p>This archive contains raw ...
Catalyst Cooperative
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Reflections on Catalyst’s legacy and future: Catalyst editors in conversation
To mark the ten-year anniversary of Catalyst: Feminism, Theory, Technoscience, former and current editors reflect on the journal\u27s origins, its contributions to feminist technoscience, and their aspirations for Catalyst in the next ten years and ...
Pienaar, Kiran +4 more
core +2 more sources
Results in EngineeringIn the present review work, the use of calcium oxide as alkaline solid catalyst for the production of biodiesel using transesterification reaction was investigated. Calcium oxide catalyst were developed from various calcium rich biomass resources.
Asfaw Adeko Tigro +2 more
doaj +1 more source