Results 71 to 80 of about 758,902 (306)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
BMC Chemistry, 2019 For the first time, the design and preparation of magnetic polyvinyl alcohol (Fe3O4@PVA) nanocomposite film as a novel nanocatalyst was accomplished by in situ precipitation method.
Ali Maleki +3 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Ti–Pd Alloys as Heterogeneous Catalysts for Hydrogen Autotransfer Reaction and Catalytic Improvement by Hydrogenation Effects [PDF]
, 2019 Ti−Pd alloys were investigated as heterogeneous catalysts for hydrogen autotransfer reactions. This is the first reported study of alloys as catalysts for hydrogen‐borrowing reactions using alcohols.
Kondo Ryota +8 more
core +1 more source
When Catalysis is Useful for Probabilistic Entanglement Transformation [PDF]
, 2004 We determine all $2\times 2$ quantum states that can serve as useful catalysts for a given probabilistic entanglement transformation, in the sense that they can increase the maximal transformation probability.
A. W. Marshall +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Scientific ReportsIn this research, graphene oxide-polyaniline (GO-PANI) nanocomposite was successfully synthesized and its catalytic performance was evaluated for the synthesis of N-aryl-1,4-dihydropyridine (1,4-DHP) and hydroquinoline derivatives. The GO nanosheets were
Hossein Ghafuri +5 more
doaj +1 more source
Co-Mn-Al mixed oxides promoted by K for direct NO decomposition: Effect of preparation parameters [PDF]
, 2019 Fundamental research on direct NO decomposition is still needed for the design of a sufficiently active, stable and selective catalyst. Co-based mixed oxides promoted by alkali metals are promising catalysts for direct NO decomposition, but which ...
Balabánová, Jana +13 more
core +2 more sources