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Catalytic Mechanism-based Design
2023In this chapter, carefully selected examples have been elaborated to illustrate how catalytic mechanism-based inhibitors can be elegantly developed for different types of enzymatic reactions involved in various life processes and therapeutic areas. Every effort has been made to ensure an updated and succinct yet comprehensive coverage of the subject ...
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Catalytic Mechanism of Fungal Homoserine Transacetylase
Biochemistry, 2005Homoserine transacetylase is a required catalyst in the biochemical pathway that metabolizes Asp to Met in fungi. The enzyme from the yeast Schizosaccharomyces pombe activates the hydroxyl group of L-homoserine by acetylation from acetyl coenzyme A. This enzyme is unique to fungi and some bacteria and presents an important new target for drug discovery.
Ishac, Nazi, Gerard D, Wright
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Quantum Mechanical Modeling of Catalytic Processes
Annual Review of Chemical and Biomolecular Engineering, 2011Advances in quantum chemical methods in combination with exponential growth in the computational speed of computers have enabled researchers in the field of catalysis to apply electronic structure calculations to a wide variety of increasingly complex problems.
Alexis T, Bell, Martin, Head-Gordon
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Formal Catalytic Mechanism of Ascorbate Oxidase
1976Ascorbate oxidase (EC 1.10.3.3), a copper enzyme widely distributed in the plant kingdom, catalyzes the oxidation of ascorbate by oxygen to the final products dehydroascorbate and water [1]. Yama-zaki and Piette [2,3] showed that the catalyzed reaction proceeds first to an ascorbyl radical, which dismutes spontaneously to ascorbate and dehydroascorbate.
S R, Burstein +3 more
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The Catalytic Mechanism of Human Transketolase
ChemPhysChem, 2019AbstractWe have computationally determined the catalytic mechanism of human transketolase (hTK) using a cluster model approach and density functional theory calculations. We were able to determine all the relevant structures, bringing solid evidences to the proposed experimental mechanism, and to add important detail to the structure of the transition ...
Prejano M. +5 more
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ADAR Proteins: Structure and Catalytic Mechanism
2011Since the discovery of the adenosine deaminase (ADA) acting on RNA (ADAR) family of proteins in 1988 (Bass and Weintraub, Cell 55:1089-1098, 1988) (Wagner et al. Proc Natl Acad Sci U S A 86:2647-2651, 1989), we have learned much about their structure and catalytic mechanism.
Rena A, Goodman +2 more
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The catalytic mechanism of carbonic anhydrase
Inorganica Chimica Acta, 1983Abstract Steady-state and equilibrium kinetic studies of the CO2HCO−3 interconversion catalyzed by human carbonic anhydrase II (or C) have led to the proposal of a mechanism scheme (Scheme 1) involving two ionizing groups [1–4]. One of these is probably a zinc-bound H2O molecule ionizing to an OH− ion which can react with CO2 to form zinc-bound HCO ...
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Photoionization reveals catalytic mechanisms
Nature Catalysis, 2022Andras Bodi +2 more
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Illuminating the mechanism of monogenic antigen expression in trypanosomes
Nature Reviews Microbiology, 2021Patryk Ludzia, Bungo Akiyoshi
exaly