Results 41 to 50 of about 12,778 (258)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Biodiesel Stability Enhancement Through Catalytic Transfer Hydrogenation Using Glycerol as Hydrogen Donor

Eng
This research aimed to enhance biodiesel stability through catalytic transfer hydrogenation using a biomimetic bimetallic catalyst and glycerol as a hydrogen donor.
Graecia Lugito, Andreas Yulius Pamungkas, Muhammad Naufaal Daffa Realdi, Alif Kembara Alam, Candra Egiyawati, Yano Surya Pradana, Tri Partono Adhi, Tatang Hernas Soerawidjaja, I Gusti Bagus Ngurah Makertihartha, Wan Hanna Melini Wan Mohtar, Irwan Kurnia, Antonius Indarto   +11 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Hydrogen transfer steps in the catalytic hydrogenolysis of cyclohexane [PDF]

Journal of Catalysis, 1971
Abstract The rate of the isotopic exchange reaction: cyclo-∗C6H12(g) + C6(g) → cyclo-C6H12(g) + ∗C6(g) (1) was studied over metal and metal oxide catalysts. C6 included: n-hexane, 2-methylpentane, 3-methylpentane, 2,2-dimethylbutane, and 2,3-dimethylbutane.
openaire   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Methods in the synthesis and conversion of 2,5-Bis-(hydroxylmethyl)furan from bio-derived 5-hydroxymethylfurfural and its great potential in polymerization

BioResources, 2018
To meet increasing demands for alternatives to fossil-based chemicals, environment-friendly and renewable energy materials are of great importance. Biomass-derived 2,5-bis-(hydroxylmethyl)furan (BHMF) has the potential to partly substitute petroleum ...
Junhua Zhang, Ting Wang, Xing Tang, Lincai Peng, Junnan Wei, Lu Lin   +5 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Unveiling the Eley–Rideal mechanism: H2 activation for nitrobenzene hydrogenation on nitrogen-doped carbon nanotubes

Carbon Future
Nitrogen-doped carbon nanotubes (NCNTs) emerge as an efficient metal-free catalyst for the hydrogenation of nitrobenzene to aniline, utilizing molecular hydrogen (H2) as the reducing agent. However, the mechanism of H2 activation on NCNTs is under debate
Hongquan Fu, Kuntao Huang, Jialong Zhang, Yonghai Cao, Hongjuan Wang, Hejun Gao, Yunwen Liao, Shuang Li, Hao Yu   +8 more
doaj   +1 more source