Results 11 to 20 of about 185,697 (300)

EPHA2 Polymorphisms and Age-Related Cataract in India [PDF]

, 2012
Objective: We investigated whether previously reported single nucleotide polymorphisms (SNPs) of EPHA2 in European studies are associated with cataract in India. Methods: We carried out a population-based genetic association study. We enumerated randomly
Maraini, G, Shanker, A, Fletcher, AE, Talwar, B, Hejtmancik, JF, Sundaresan, P, Ravindran, RD, Nonyane, BAS, Vashist, P, Smeeth, Liam, Camparini, M, Nitsch, D, Chakravarthy, U   +12 more
core   +5 more sources

Deconstruction of Human Age-Related Cataract Capsules Defines Aging. [PDF]

Adv Sci (Weinh)
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Tang Q, Tong Z, Fan C, Chen S, Guo J, Hu J, Yao K, Yin Z, Chen X, Yu Y.   +9 more
europepmc   +2 more sources

Cataract [PDF]

Nature Reviews Disease Primers, 2015
Cataract is the leading cause of reversible blindness and visual impairment globally. Blindness from cataract is more common in populations with low socioeconomic status and in developing countries than in developed countries. The only treatment for cataract is surgery.
Lam, Dennis, Rao, Srinivas K., Ratra, Vineet, Liu, Yizhi, Mitchell, Paul, King, Jonathan, Tassignon, Marie-José, Jonas, Jost, Pang, Chi P., Chang, David F.   +9 more
openaire   +5 more sources

Cataract and surgery for cataract [PDF]

BMJ, 2006
Cataract surgery is the commonest single surgical procedure carried out in the developed world. In the developing world, cataract remains the commonest cause of blindness. In 1990 an estimated 37 million people were blind worldwide—40% of them because of cataract.1 Every year, an extra 1-2 million people go blind.
David, Allen, Abhay, Vasavada
openaire   +2 more sources

Years of sunlight exposure and cataract: a case-control study in a Mediterranean population. [PDF]

, 2007
BACKGROUND: We aimed to investigate the relation between sunlight exposure and risk of cataract. METHODS: We carried out a frequency-matched case-control study of 343 cases and 334 controls attending an ophthalmology outpatient clinic at a primary health-
Pastor-Valero, María, Fletcher, Astrid E, de Stavola, Bianca L, Chaqués-Alepúz, Vicente   +3 more
core   +2 more sources

Femtosecond laser-assisted cataract surgeries reported to the European Registry of Quality Outcomes for Cataract and Refractive Surgery : baseline characteristics, surgical procedure, and outcomes [PDF]

, 2018
Purpose To describe a large cohort of femtosecond laser-assisted cataract surgeries in terms of baseline characteristics and the related outcomes. Setting Eighteen cataract surgery clinics in 9 European countries and Australia.
Manning, Sonia, Rosen, Paul, Lundström, Mats, Dickman, Mor, Stenevi, Ulf, European Society of Cataract and Refractive Surgeons Femtosecond Laser–Assisted Cataract Surgery Study Collaborators, Henry, Ype, Tassignon, Marie-José, Young, David   +8 more
core   +4 more sources

Preoperative visual acuity among cataract surgery patients and countries' state of development: a global study. [PDF]

, 2011
OBJECTIVE: To describe the preoperative surgical case mix among patients undergoing cataract extraction and explore associations between case mix, country level of development (as measured by the Human Development Index, HDI) and cataract surgery rates ...
Razavi, H, Turner, EL, Claire Gilbert, Robert J Lindfield, Robert Lindfield, Lindfield, Robert J, Shaheen Shah, Elizabeth Turner, Gilbert, Clare E, Int Eye Res, N, International Eye Research Network, Shah, SP, Claire E Gilbert, Razavi, Hessom, Shaheen P Shah, Hessom Razavi, Elizabeth L Turner, Gilbert, CE, Shah, Shaheen P, Turner, Elizabeth L, Lindfield, RJ, on behalf of the International Eye Research Network, Gilbert, Claire E   +22 more
core   +1 more source

Blindness and visual impairment due to age-related cataract in sub-Saharan Africa: a systematic review of recent population-based studies. [PDF]

, 2013
AIM: We aimed to evaluate age-related cataract as a contributor to blindness and visual impairment (VI) in sub-Saharan Africa (SSA). METHODS: A systematic review of population-based studies published between 2000 and October 2012.
Sherwin, Justin C, Bastawrous, Andrew, Dean, William H   +2 more
core   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Cataract surgery in Southern Ethiopia: distribution, rates and determinants of service provision. [PDF]

, 2013
BACKGROUND: Cataract is the leading cause of blindness worldwide, with the greatest burden found in low-income countries. Cataract surgery is a curative and cost-effective intervention.
Habtamu, Esmael, Burton, Matthew J, Esmael Habtamu, Zebiba Eshete, Matthew J Burton, Eshete, Zebiba   +5 more
core   +2 more sources