Results 31 to 40 of about 192,260 (303)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Two point four million cataract surgeries: 30 years with the Swedish National Cataract Register, 1992-2021

, 2023
The present review summarizes data collected by the Swedish National Cataract Register (NCR), which by the end of 2021 contained data for more than 2.4 million cataract surgeries between 1992 and 2021.
Bro, Tomas,, Lundström, Mats, Behndig, A, Thorburn, W, Zetterberg, Madeleine, Tomas Bro, Nilsson, I, Nilsson, Ingela, Stenevi, Ulf, Lundstrom, M, Viberg, Andreas,, Maria Kugelberg, Bro, T, Anders Behndig, Madeleine Zetterberg, Bro, Tomas, Mats Lundström, Ingela Nilsson, Stenevi, Ulf,, Viberg, Andreas, Behndig, Anders,, Kugelberg, Maria,, Viberg, A, Zetterberg, Madeleine,, Andreas Viberg, William Thorburn, Thorburn, William,, Stenevi, U, Zetterberg, M, Kugelberg, M,, Ulf Stenevi, Nilsson, Ingela,, Lundström, Mats,, Thorburn, William, Kugelberg, Maria, Lund University., Behndig, Anders   +36 more
core   +1 more source

Real‐World Effectiveness and Safety of Secukinumab in Giant Cell Arteritis: An Italian Multicenter Cohort Study

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to evaluate the real‐world effectiveness and safety of secukinumab in patients with giant cell arteritis (GCA). Methods This multicenter retrospective study included patients with GCA who received secukinumab at 14 Italian centers with at least six months of follow‐up.
Luca Iorio, Federica Davanzo, Caterina Ricordi, Milena Bond, Ruggiero Mascolo, Jacopo Mora, Alessandro Tomelleri, Angelo Fassio, Francesca Cuzzocrea, Sara Monti, Edoardo Conticini, Fabiola Atzeni, Paolo Delvino, Carlotta Nannini, Augusta Ortolan, Francesco Pollastri, Ester Vivaldelli, Chiara Marvisi, Paola Toniati, Antonio Brucato, Alessandra Milanesi, Francesca Regola, Enrico Tombetti, Lorenzo Dagna, Roberta Ramonda, Christian Dejaco, Luca Quartuccio, Carlo Salvarani, Roberto Padoan   +28 more
wiley   +1 more source

Femtosecond laser-assisted cataract surgeries reported to the European Registry of Quality Outcomes for Cataract and Refractive Surgery : baseline characteristics, surgical procedure, and outcomes [PDF]

, 2018
Purpose To describe a large cohort of femtosecond laser-assisted cataract surgeries in terms of baseline characteristics and the related outcomes. Setting Eighteen cataract surgery clinics in 9 European countries and Australia.
Manning, Sonia, Rosen, Paul, Lundström, Mats, Dickman, Mor, Stenevi, Ulf, European Society of Cataract and Refractive Surgeons Femtosecond Laser–Assisted Cataract Surgery Study Collaborators, Henry, Ype, Tassignon, Marie-José, Young, David   +8 more
core   +1 more source

Elimination of avoidable blindness due to cataract: where do we prioritize and how should we monitor this decade? [PDF]

, 2012
BACKGROUND: In the final push toward the elimination of avoidable blindness, cataract occupies a position of eminence for the success of the Right to Sight initiative. AIMS: Review existing situation and assess what monitoring indicators may be useful to
Murthy, Gudlavalleti VS, Hira B Pant, Neena John, John, Neena, Pant, Hira B, Gudlavalleti VS Murthy, Shamanna, Bindiganavale R, Bindiganavale R Shamanna   +7 more
core   +1 more source

Advanced Flexible Robotic Systems for the Early Diagnosis and Treatment of Cancer and Cardiovascular Diseases

Advanced Robotics Research, EarlyView.
Flexible surgical robots are advancing minimally invasive interventions for cardiovascular diseases and cancer by enabling precise navigation through complex, submillimeter anatomical pathways. This review highlights recent innovations in actuation, bio‐integrated sensing, AI‐assisted control, and friction‐reduction technologies, discusses current ...
Hermione Truong, Chi Cong Nguyen, Hannah Thuy Truong, Kefan Zhu, Adrienne Ji, James Davies, Emanuele Nicotra, Bibhu Sharma, Jingjing Wan, Patrick Pruscino, Shing Wai Wong, Hoang‐Phuong Phan, Phuoc Thien Phan, Nigel H. Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Christmas Tree Cataract - A Cataract that Glitters

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016
A 54-year-old man presented to the Ophthalmology OPD with redness and discharge from his eyes. His vision was 20/20 in both the eyes. There was diffuse conjunctival congestion and mild discharge in both the eyes. On detailed examination, the left eye showed highly refractive, multi-coloured, iridescent crystals in the inferior cortex and nucleus of the
Tanie Natung, Lanalyn Thangkhiew, Avonuo Keditsu, Wakaru Shullai   +3 more
openaire   +3 more sources

Further genetic heterogeneity for autosomal dominant human sutural cataracts [PDF]

, 2003
A unique sutural cataract was observed in a 4-generation German family to be transmitted as an isolated autosomal, dominant trait. Since mutations in the gamma-crystallin encoding CRYG genes have previously been demonstrated to be the most frequent ...
Graw, Jochen, Illig, T., Billingsley, G., Wjst, M., Graw, J., Rudolph, G., Klopp, N., Heon, E., Klopp, N.;Heon, E.;Billingsley, G.;Illig, T.;Wjst, M.;Rudolph, G.;Graw, J.   +8 more
core   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source