Results 141 to 150 of about 7,056 (256)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Functional orthopedic treatment for mandibular asymmetry in a giant panda with amputation. [PDF]

Angle Orthod
Fan Q, Li J, Alkam E, You M, Luo L, Li B, Huang W, Chen X, Han X, Lai W, Long H.   +10 more
europepmc   +1 more source

Hunting Strategies and Game Exploitation Organization in the Magdalenian: An Integrated Approach Based on Mortality Profiles and Stable Isotopes at Chaves Cave (Huesca, Spain)

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Understanding hunting strategies in Upper Paleolithic contexts remains challenging due to the complex relationships between prey behavior, environmental conditions, and human decision‐making. Addressing these dynamics requires integrating archeozoological, geospatial, and geochemical proxies capable of capturing demographic patterns, landscape
Alejandro Sierra, Marie Balasse, Luis Jiménez, Rafael Domingo, Lourdes Montes, Denis Fiorillo, Pilar Utrilla   +6 more
wiley   +1 more source

Structural dynamics of the midnolin-proteasome during ubiquitin-independent substrate turnover. [PDF]

Nat Commun
Zhu C, Qin L, Dai Z, Zuo P, Yang A, Zhong L, Lin Z, Liang L.   +7 more
europepmc   +1 more source

Rethinking Public Administration Reform: Institutional Layering of Bureaucratic, Managerial and Community Logics Over Time in Nigeria's Tax Administration

Public Administration and Development, EarlyView.
ABSTRACT The reform of public institutions has attracted sustained attention in both scholarship and policymaking. Increasingly, however, there is growing recognition that reforms are rarely implemented in an institutional vacuum. Instead, new reforms are layered onto existing arrangements, producing hybrid institutional landscapes shaped by prior ...
Edidiong Bassey
wiley   +1 more source

Real-time IVUS-guided retrieval of a coronary retained guidewire fragment: A case report. [PDF]

Radiol Case Rep
Tchassem Dimdie A, Al Barajraji M, Mairesse GH, Dechaux D, Massart PE, Jamart L.   +5 more
europepmc   +1 more source

What is ‘relational thinking’, and how does it manifest in research?

People and Nature, EarlyView.
Abstract People and Nature is a ‘journal of relational thinking’. This editorial explores what relational thinking can mean and how it might be operationalized in the context of humans and the environment. Relational thinking may seem intuitive because it recognizes the world's inherent interconnectedness. However, the question of how to operationalize
Rachelle K. Gould, Stefan Partelow, Kevin J. Gaston, Tobias Plieninger, Helen E. Roy, Robert Fish, Andrea Rawluk   +6 more
wiley   +1 more source

Clustering and a conformational switch drive activation of the mammalian receptor tyrosine kinase ROS1. [PDF]

Nat Commun
Li H, Zhang J, Li T, Wang Y, Alarcón CR, Klein DE.   +5 more
europepmc   +1 more source

Prevalence of shoulder subluxation diagnosed via ultrasound screening in infants with birth brachial plexus injuries

PM&R, EarlyView.
Abstract Introduction Posterior shoulder subluxation and glenohumeral dysplasia are known secondary complications of birth brachial plexus palsies (BBPP) that contribute to functional limitations. The prevalence of shoulder subluxation in infants with BBPP and the timeline of when subluxation occurs in the first year of life remain unclear, with prior ...
Gabrielle Goodlin, Sarah Lewis, Sarah Menashe, Ramesh Iyer, Raymond Tse, Marisa Osorio   +5 more
wiley   +1 more source

A shared code for perceiving and imagining objects in human ventral temporal cortex. [PDF]

Science
Wadia VS, Reed CM, Chung JM, Bateman LM, Mamelak AN, Rutishauser U, Tsao DY.   +6 more
europepmc   +1 more source