Results 1 to 10 of about 5,625 (181)

Different Catechol-O-Methyl Transferase Inhibitors in Parkinson's Disease: A Bayesian Network Meta-Analysis [PDF]

Frontiers in Neurology, 2021
Parkinson's disease (PD) is a common, chronic, progressive, debilitating neurodegenerative disease. The current levodopa treatment requires the addition of other drugs, such as catechol-O-methyl transferase (COMT) inhibitors, to alleviate motor ...
Zhaoming Song, Jie Zhang, Tao Xue, Yanbo Yang, Da Wu, Zhouqing Chen, Wanchun You, Zhong Wang   +7 more
doaj   +3 more sources

Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity. [PDF]

Int J Neuropsychopharmacol, 2014
Catechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for attentional and cognitive deficits in both psychotic and healthy individuals.
Moskovitz J, Walss-Bass C, Cruz DA, Thompson PM, Bortolato M.   +4 more
europepmc   +6 more sources

Inhibiting microtubule polymerization with EAPB02303, a prodrug activated by catechol-O-methyl transferase, enhances paclitaxel effect in pancreatic cancer models [PDF]

Cell Death and Disease
The Imiqualines family is an original group of small heterocyclic compounds, diversely substituted around different scaffolds. Among these compounds, the lead EAPB02303 displays outstanding cytotoxic activity at nanomolar concentrations comparable to ...
Kévin Bigot, Cindy Patinote, Véronique Garambois, Adrien Chouchou, Stéphanie Gayraud-Paniagua, Nadia Vie, Yann Maggipinto, Elias Smyej, Mathilde Robin, Margot Machu, Marine Bruciamacchie, Pierre-Emmanuel Colombo, Corinne Bousquet, Muriel Mathonnet, Ela Levy-Augé, Diego Tosi, Pierre-Antoine Bonnet, Céline Gongora, Carine Deleuze-Masquéfa, Christel Larbouret   +19 more
doaj   +4 more sources

The inconsistent mediating effect of catechol O methyl transferase Val158Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients [PDF]

Frontiers in Psychiatry, 2022
ObjectiveSchizophrenia is a multifaceted mental disorder characterized by heterogeneous positive/negative symptoms and cognitive deficits. Sex differences have been reported in various aspects of the disease.
Hang Xu, Yongjie Zhou, Meihong Xiu, Dachun Chen, Weiwen Wang, Weiwen Wang, Li Wang, Li Wang, Xiangyang Zhang, Xiangyang Zhang   +9 more
doaj   +2 more sources

Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microglia. [PDF]

Neurosci Lett, 2007
Outcome following traumatic brain injury (TBI) is in large part determined by the combined action of multiple processes. In order to better understand the response of the central nervous system to injury, we utilized an antibody array to simultaneously screen 507 proteins for altered expression in the injured hippocampus, a structure critical for ...
Redell JB, Dash PK.
europepmc   +6 more sources

Catechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer [PDF]

Scientific Reports, 2023
Catechol-O-methyl transferase (COMT) is involved in detoxification of catechol estrogens, playing cancer-protective role in cells producing or utilizing estrogen. Moreover, COMT suppressed migration potential of breast cancer (BC) cells.
Lucia Janacova, Michaela Stenckova, Petr Lapcik, Sarka Hrachovinova, Pavla Bouchalova, David Potesil, Roman Hrstka, Petr Müller, Pavel Bouchal   +8 more
doaj   +2 more sources

Association of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia

Journal of Research in Medical Sciences, 2009
<font face="TimesNewRoman,Bold" size="1"><font face="TimesNewRoman,Bold" size="1"><ul><li><div align="left"><strong>BACKGROUND</strong>: <font face="TimesNewRoman" size="2"><font face="TimesNewRoman ...
mir davood omrani, Soroush Bazargani, Morteza bagheri   +2 more
doaj   +3 more sources

1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action against Parkinson’s Disease [PDF]

Molecules, 2022
Two analogues of tolcapone where the nitrocatechol group has been replaced by a 1-hydroxy-2(1H)-pyridinone have been designed and synthesised. These compounds are expected to have a dual mode of action both beneficial against Parkinson’s disease: they ...
Joseph C. J. Bergin, Kean Kan Tan, Anya K. Nelson, Cristina-Andreea Amarandei, Véronique Hubscher-Bruder, Jérémy Brandel, Varvara Voinarovska, Annick Dejaegere, Roland H. Stote, David Tétard   +9 more
doaj   +2 more sources

Membrane-bound catechol-O-methyl transferase in cortical neurons and glial cells is intracellularly oriented [PDF]

Frontiers in Psychiatry, 2010
Catechol-O-methyl transferase (COMT) is involved in the inactivation of dopamine in brain regions in which the dopamine transporter (DAT1) is sparsely expressed.
Björn H Schott, Björn H Schott, Björn H Schott, Renato Frischknecht, Grazyna eDebska-Vielhaber, Grazyna eDebska-Vielhaber, Nora John, Gusalija Behnisch, Emrah eDüzel, Emrah eDüzel, Emrah eDüzel, Eckart D Gundelfinger, Constanze I Seidenbecher   +12 more
doaj   +2 more sources

Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia

Journal of Pharmacy & Pharmaceutical Sciences, 2018
Purpose. Parkinson's disease (PD), a common neurodegenerative disorder, is usually treated with Levodopa (L-DOPA). The use of this drug, however, is severely limited by the development of side effects of the motor system: Levodopa-induced dyskinesia (LID)
Svetlana A. Ivanova, Valentina M. Alifirova, Ivan V. Pozhidaev, Maxim B. Freidin, Irina A. Zhukova, Diana Z. Osmanova, Natalia G. Zhukova, Yulia A. Mironova, Vladimir V. Tiguntsev, Olga Yu. Fedorenko, Nikolay A. Bokhan, Bob Wilffert, Anton J.M. Loonen   +12 more
doaj   +3 more sources