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Comparative Safety of Istradefylline Among Parkinson Disease Adjunctive Therapies: A Systematic Review and Meta-analysis of Randomized Controlled Studies. [PDF]
Clin NeuropharmacolTorres-Yaghi Y +7 more
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Catechol-O-methyl transferase in human erythrocytes
Naunyn-Schmiedeberg's Archives of Pharmacology, 1972Washed human red cells, suspended in an isotonic electrolyte solution, were incubated with radioactive catecholamines (epinephrine, norepinephrine, dopamine and isoproterenol). Their conversion to 3-O-methyl derivatives was demonstrated by ion exchange chromatography for each substrate.
Heinrich F. K. M�nnl +2 more
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Catechol-o-methyl Transferase Activity in Skeletal Muscle
Nature, 1966IT has been reported that catechol-o-methyl transferase (COMT) is found in most organs of the rat except skeletal muscle1. In the course of studies on the isolation of this enzyme from various tissues, we obtained results indicating that muscle shows a COMT activity approaching that found in the lungs and heart.
M, Assicot, C, Bohuon
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Effect of Catechol O-Methyl Transferase in Schizophrenia
Archives of General Psychiatry, 1969THE WRITERS have attempted to treat a group of patients suffering from schizophrenia with catechol O-methyl transferase (OMT). It has been suggested that there may be a genetic deficiency of this enzyme in schizophrenia, either leading to inability to demethylate dietary dimethoxyphenylethylamine 1 or causing disturbance in melanin metabolism with the ...
P, Hall, G, Hartridge, G H, van Leeuwen
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Catechol-O-methyl transferase in mouse liver plasma membranes
Biochemical and Biophysical Research Communications, 1975Abstract Catechol-o-methyl transferase is usually localized predominantly in the cytosol fraction of cells, but fractionation of mouse liver showed plasma membranes contain ∼ 70% of the total enzyme activity and have a specific activity ∼ 10x greater than the cytosol fraction.
J R, Aprille, D F, Malamud
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Catechol-O-Methyl Transferase Activity in the Human Term Placenta
American Journal of Perinatology, 1988Catechol-O-methyltransferase (COMT) characteristics and activity were studied using radioenzymatic techniques in placentas from normal and high-risk patients at term. The affinity of the catechol estrogen 20-hydroxyestrone (2OHE1), Km = 5 microM, for the enzyme was found to be at least 90-fold higher than that of the catecholamines norepinephrine ...
E R, Barnea +3 more
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A radioisotope method for catechol-o-methyl transferase in blood
Clinica Chimica Acta, 1972Abstract A method for the determination of S-adenosylmethionine O-diphenol O-methyl-transf erase (E.C. 2.1.1.6) is described, basedon the measurement of radioactive metanephrine produced by the action of the enzyme on labelled epinephrine. The metanephrine is extracted by toluene-isoamyl alcohol and estimated in a liquid scintillation counter. Using
J, Griffiths, H, Linklater
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Catechol-O-Methyl Transferase as a Drug Target for Schizophrenia
CNS & Neurological Disorders - Drug Targets, 2012Current antipsychotic drugs lack material efficacy against the negative symptoms and cognitive deficits of schizophrenia. There is considerable uncertainty regarding the optimal pharmacotherapeutic strategy for treating these and other aspects of psychotic illness.
Colm M P, O'Tuathaigh +3 more
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