Results 151 to 160 of about 5,625 (181)
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Inhibition of catechol-o-methyl transferase by catechols and polyphenols
Biochemical Pharmacology, 1973Abstract The effects of the polyphenolic decarboxylase inhibitor, N1-(d,l-seryl)-N2-(2,3,4-Trihydroxybenzyl)-hydrazine (RO4-4602), were compared with the effects of dopa and pyrogallol as inhibitors of catechol-o-methyl transferase (COMT). The apparent Km, for [3H]norepinephrine as the substrate was 0.36 mM.
R J, Baldessarini, E, Greiner
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[3H]Norepinephrine binding: Unrelated to catechol-o-methyl transferase
Biochemical and Biophysical Research Communications, 1974Summary [ 3 H]norepinephrine binds in vitro to microsomal membranes derived from a wide variety of tissues. Controversy exists as to the physiological significance of this binding phenomenon and recently the suggestion has been made that this represents binding to the enzyme catechol-o-methyl transferase (COMT).
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Catechol-O-Methyl Transferase (COMT) Activity Detection Using Metal Oxide Electrodes
ECS Meeting Abstracts, 2020Parkinson’s disease is one of the most frequent diseases of the central nervous system with rather severe consequences for patients. Since the disorder can not be cured, the dopamine level in the brain needs to adjusted. Here several key enzymes of the dopamine metabolism [e. g.
Gero Göbel, Fred Lisdat
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Hormonal influences on erythrocyte catechol-O-methyl transferase activity in humans
Experientia, 1973Dans le cas de beaucoup de femmes prenant des contraceptifs oraux, l'activite du transferase catechole-O-methyle du globule rouge est reduite a des nivaux analogues a ceux observes dans le cas de femmes souffrant de depression non-traitee. Le depot de contraceptifs a action durable n'affecte pas d'une maniere significative l'enzyme, bien qu'elle soit ...
M H, Briggs, M, Briggs
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Metabolism of L-dopa after inhibition of catechol-O-methyl transferase
European Journal of Pharmacology, 1972Abstract Rats were given inhibitors of cathecol-O-methyltransferase followed by 3 H-L-dopa or 3 H-norepinephrine. In the brain, pyrogallol led to marked increases of unmetabolized 3 H-L-dopa and to greater accumulations of labelled catecholamines and deaminated catechols, but to decreases of O-methylated metabolites.
R J, Baldessarini, K V, Chace
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The Catechol-O-Methyl Transferase Val158Met Polymorphism and Susceptibility to Cannabis Dependence
American Journal of Forensic Medicine & Pathology, 2008Cannabis stimulates dopamine release and activates dopaminergic reward neurons in central pathways that lead to enhanced dependence. Catechol-O-methyl transferase (COMT) inactivates amplified extraneuronally released dopamine. A functional polymorphism (COMT Val158Met) resulting in increased enzyme activity has been associated with polysubstance abuse ...
Aysun Baransel, Baransel Isir +5 more
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A Twin Study of Human Red Blood Cell Catechol-O-Methyl Transferase
British Journal of Psychiatry, 1976SummarySignificant sibling-sibling and within-family correlations of human red blood cell catechol-o-methyl transferase activity have suggested a high degree of genetic control over levels of activity of this catecholamine-related enzyme. However, family studies do not disentangle genetic from environmental similarities as causative of within-family ...
L, Grunhaus +4 more
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Biochemical Pharmacology, 1965
Abstract Papaverine was demethylated chemically to yield desmethylpapaverine (papaveroline). In low and intermediate concentrations it moderately potentiated contractions, of isolated aortic strip of rabbit, induced by epinephrine, angiotensin, and potassium (nonspecific potentiation); in higher concentrations it markedly potentiated the epinephrine-
J V, Burba, M F, Murnaghan
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Abstract Papaverine was demethylated chemically to yield desmethylpapaverine (papaveroline). In low and intermediate concentrations it moderately potentiated contractions, of isolated aortic strip of rabbit, induced by epinephrine, angiotensin, and potassium (nonspecific potentiation); in higher concentrations it markedly potentiated the epinephrine-
J V, Burba, M F, Murnaghan
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Reproductive Sciences, 2008
The effects of estrogen and progesterone on the expression of estrogen-metabolizing enzymes such as catechol-O-methyl transferase (COMT) are not known. COMT converts genotoxic catecholestrogens to anticarcinogenic methoxyestrogens in the endometrium.
Salih, SM +7 more
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The effects of estrogen and progesterone on the expression of estrogen-metabolizing enzymes such as catechol-O-methyl transferase (COMT) are not known. COMT converts genotoxic catecholestrogens to anticarcinogenic methoxyestrogens in the endometrium.
Salih, SM +7 more
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Effect of a catechol-O-methyl transferase inhibitor, U-0521, with levodopa administration
Biochemical Pharmacology, 1979Abstract The in vivo effect of 3,4-dihydroxy-2-methyl-propriophenone (U-0521) was studied in rats treated with l -Dopa, 250 mg/kg, intraperitoneally. In a time-course study, experimental animals received two doses of U-0521, 250 mg/kg, i.p., 30 min before l -Dopa and along with l -Dopa. Rats were decapitated at intervals of 30–120 min.
S, Fahn +3 more
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