Results 31 to 40 of about 5,625 (181)
Neurology International, 2020 Parkinson’s disease (PD) is a common neurodegenerative disorder that leads to significant morbidity and disability. PD is caused by a loss of dopaminergic, cholinergic, serotonergic, and noradrenergic neurons in the central nervous system (CNS), and ...
Amnon A. Berger +8 more
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Management of OFF condition in Parkinson disease [PDF]
Mental Health Clinician, 2023 Parkinson disease (PD) impacts nearly 1 million individuals in the United States. Nearly every patient with PD will require therapy with dopamine in the form of levodopa as the disease progresses.
Jessa Koch, PharmD, BCPP, APh
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Platelet-mediated metabolism of the common dietary flavonoid, quercetin. [PDF]
PLoS ONE, 2010 Flavonoid metabolites remain in blood for periods of time potentially long enough to allow interactions with cellular components of this tissue. It is well-established that flavonoids are metabolised within the intestine and liver into methylated ...
Bernice Wright +4 more
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Prediction of schizophrenia using MAOA-uVNTR polymorphism: A case–control study
Indian Journal of Psychiatry, 2020 Context: Schizophrenia has been associated with disorder of the dopamine system, which is downregulated by projections of the serotonin pathway. Dopamine and serotonin levels are regulated by a system of transporters and enzymes.
Jelena Culej +3 more
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In Vivo Biosynthesis and Direct Incorporation of Noncanonical Amino Acids into Proteins. [PDF]
ChembiochemThis review evaluates engineered (semi)autonomous cell systems for the biosynthesis and incorporation of noncanonical amino acids (ncAAs) into proteins. While semi‐autonomous cells convert supplied precursors into ncAAs autonomous cells integrate biosynthetic pathways that produce these building blocks intracellularly.
Illies JH, Weber TM, Drienovská I.
europepmc +2 more sources
Loss of physical contact in space alters the dopamine system in C. elegans
iScience, 2022 Summary: Progressive neuromuscular decline in microgravity is a prominent health concern preventing interplanetary human habitation. We establish functional dopamine-mediated impairments as a consistent feature across multiple spaceflight exposures and ...
Surabhi Sudevan +11 more
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Variants in COMT, CYP3A5, CYP2B6, and ABCG2 Alter Quetiapine Pharmacokinetics
Pharmaceutics, 2021 Quetiapine is an atypical antipsychotic widely used for the treatment of schizophrenia and the depressive episodes of bipolar disorder. The aim of this work was to investigate the effect of variants in relevant pharmacogenes in the pharmacokinetics of ...
Pablo Zubiaur +8 more
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Consensus Guideline for the Diagnosis and Treatment of Tyrosine Hydroxylase (TH) Deficiency. [PDF]
J Inherit Metab DisABSTRACT Tyrosine hydroxylase (TH) catalyses the rate‐limiting step in dopamine biosynthesis. Autosomal recessive tyrosine hydroxylase deficiency (THD) leads to clinical phenotypes reflecting the deficiency of dopamine, norepinephrine, or epinephrine in the central nervous system (CNS), presenting along a continuous spectrum from mild to severe forms ...
Bondarenko MS +19 more
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Dopamine System Dysfunction in Alzheimer's Disease. [PDF]
PsychogeriatricsABSTRACT The dopaminergic system may be at the base of some neurobehavioral symptoms, as apathy and depression, and extrapyramidal symptoms, often seen in Alzheimer's disease patients. It can also have an impact on cognitive decline, as extrapyramidal symptoms, classically linked with dopamine dysfunction, are associated with increased risk of ...
Moreira IP +2 more
europepmc +2 more sources
Balkan Journal of Medical Genetics, 2020 Catechol-O-methyl transferase (COMT) enzyme has a role in the inactivation of catecholamine neurotransmitters. Functional polymorphism in the COMT gene has been reported to play an important role in schizophrenia, bipolar affective disorder, aggressive ...
Nennicioglu Y +5 more
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