Results 41 to 50 of about 5,625 (181)

Isoliquiritigenin Alleviates Semen Strychni-Induced Neurotoxicity by Restoring the Metabolic Pathway of Neurotransmitters in Rats

Frontiers in Pharmacology, 2021
Acute neurotoxicity of Semen Strychni can result in sudden death in epilepsy. The detoxification method and mechanism of Semen Strychni acute poisoning have not been clarified.
Lu Wang, Lu Wang, Min Zhang, Min Zhang, Jing Wen, Yalan Xiang, Yalan Xiang, Xiaoyu Duan, Xiaoyu Duan, Changwei Yu, Changwei Yu, Miao Yan, Miao Yan, Bikui Zhang, Bikui Zhang, Pingfei Fang, Pingfei Fang   +16 more
doaj   +1 more source

Catechol-O-Methyltransferase Val158Met and brain-derived neurotrophic factor Val66Met gene polymorphisms in paraphilic sexual offenders

Indian Journal of Psychiatry, 2019
Background: Child sexual abuse (CSA) is an important problem worldwide. The reason of sex abuse is considered as multifactorial. Genetic contribution reported by recent studies is a significant evidence for this pathologic behavior.
Mujgan Cengiz, Esma Cezayirli, Burcu Bayoglu, Hizir Asliyuksek, Nese Kocabasoglu   +4 more
doaj   +1 more source

In vitro and in vivo characterization of Entacapone-loaded nanostructured lipid carriers developed by quality-by-design approach

Drug Delivery, 2022
Entacapone, a reversible catechol-o-methyl transferase inhibitor, is used to enhance the action of dopamine agonists by reducing their metabolism and the ‘Wearing-off’ effects associated with long-term use in the treatment of Parkinson's disease.
Yogeeta Agrawal, Kiran Patil, Hitendra Mahajan, Mrugendra Potdar, Pratiksha Joshi, Kartik Nakhate, Charu Sharma, Sameer N. Goyal, Shreesh Ojha   +8 more
doaj   +1 more source

Catechol-O-methyl transferase and schizophrenia.

Psychiatria Danubina, 2010
Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity.
Šagud, Marina, Műck-Šeler, Dorotea, Mihaljević-Peleš, Alma, Vuksan-Ćusa, Bjanka, Živković, Maja, Jakovljević, Miro, Pivac, Nela   +6 more
openaire   +6 more sources

Concentration of norepinephrine, serotonin, and histamine, and of amine-metabolizing enzymes in mammalian adipose tissue

Journal of Lipid Research, 1963
The norepinephrine content of adipose tissue is shown to be very different in various animal species and different sites of origin, ranging from 0.03-1.4 μg/g. Adipose tissue also contains considerable amounts of serotonin (0.01-1.04 μg/g) and histamine (
K. Stock, E.O. Westermann
doaj   +1 more source

CATECHOLAMINE ASSAY BY RADIOENZYMATIC METHOD - A PROTOCOL

Journal of the Dow University of Health Sciences, 2008
Catecholamines are a group o f compounds identified by the catechol nucleus. The significant catecholamines found naturally in the body are epinephrine, nor- epinephrine and dopamine.
Nasim Karim, Joshua R. berlin
doaj   +2 more sources

Disorganization, COMT, and Children’s Social Behavior: The Norwegian Hypothesis of Legacy of Disorganized Attachment

Frontiers in Psychology, 2016
Why is disorganized attachment associated with punitive-controlling behavior in some, but caregiving-controlling in others? Hygen and associates (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this ...
Zhi Li, Beate Wold Hygen, Keith Widaman, Turid Suzanne Berg-Nielsen, Lars Wichstrøm, Lars Wichstrøm, Jay Belsky   +6 more
doaj   +1 more source

Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone’s Particle Size on Sustained Release

Pharmaceutics, 2020
Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase.
Anna Nardi-Ricart, Isaac Nofrerias-Roig, Marc Suñé-Pou, Pilar Pérez-Lozano, Montse Miñarro-Carmona, Encarna García-Montoya, Josep R. Ticó-Grau, Raul Insa Boronat, Josep M. Suñé-Negre   +8 more
doaj   +1 more source

Playing nice: A multi-methodological study on the effects of social conformity on memory

Frontiers in Human Neuroscience, 2013
Conformity is an important aspect of social behavior. Two main motives have been identified: people may adapt their behavior to play nice despite knowing better (normative conformity) or they may accept the others’ opinion as a valid source of ...
Lorena eDeuker, Anna Renuka Müller, Christian eMontag, Sebastian eMarkett, Martin eReuter, Martin eReuter, Juergen eFell, Peter eTrautner, Nikolai eAxmacher, Nikolai eAxmacher   +9 more
doaj   +1 more source

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source