Results 51 to 60 of about 5,625 (181)

Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review

Food Safety and Health, EarlyView.
Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra, Monika Bhadauria, Satendra Kumar Nirala   +2 more
wiley   +1 more source

Considerations for Initiation and Maintenance of Foslevodopa/Foscarbidopa for Advanced Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background As Parkinson's disease (PD) progresses, motor fluctuations become increasingly difficult to manage with oral medications. Foslevodopa/foscarbidopa (LDp/CDp), delivered as a continuous 24‐h/day subcutaneous infusion, offers continuous levodopa delivery and stable plasma levodopa levels that reduce motor fluctuations. LDp/CDp has been
K. Ray Chaudhuri, Bruno Bergmans, Eric Freire‐Alvarez, Lucie Hopes, Drew S. Kern, Robert S. Kirsner, Giulia Lazzeri, Pedro Mendes‐Bastos, Noriko Nishikawa, Per Odin, Karolina Poplawska‐Domaszewicz, Rajesh Pahwa, Yuval Ramot, Klaus Seppi, Tobias Warnecke, Robert Wiggins, Megha B. Shah, Pavnit Kukreja, Bjoern Fritz, Koray Onuk, Stuart H. Isaacson   +20 more
wiley   +1 more source

Catalysis: transition-state molecular recognition?

Beilstein Journal of Organic Chemistry, 2010
The key to understanding the fundamental processes of catalysis is the transition state (TS): indeed, catalysis is a transition-state molecular recognition event.
Ian H. Williams
doaj   +1 more source

A Pseudo‐Mytilus Edulis Foot Protein‐Based Hydrogel Adhesive with Osteo‐Vascular‐Immune Coupling Effects for Osteoporotic Bone‐Implant Integration

Advanced Materials, Volume 38, Issue 6, 27 January 2026.
Inspired by mussel proteins, YDC‐Gel‐Zn is a smart bone glue designed for osteoporotic implants. It adheres strongly to both metal implants and bone for initial fixation. In osteoporosis's inflammatory environment, it sequentially releases zinc ions and therapeutic peptides: the zinc modulates immune cells to reduce inflammation, while the peptides ...
Wentao Wang, Zhenyu Li, Siming Zhang, Yue Ma, Lei Yu, Qidong Zhang, Guoqing Pan, Dechun Geng, Chen Zhu, Jiaxiang Bai   +9 more
wiley   +1 more source

Acidogenesis‐Propelled Coordination Transition in Light‐Triggered Fe‐Polyphenol Polymer for Reactive Oxygen Species‐Augmented Antitumor Therapy

Advanced Science, Volume 12, Issue 47, December 18, 2025.
A novel iron‐polyphenol‐photoacid coordination polymer (FeBPs) is designed to achieve red light‐triggered external acidification and internal coordination regulation, where this light‐controlled acidification induces coordination changes that enhance Fe active site exposure and provide H+ for beneficial Fe3+/Fe2+ conversion, thereby accelerating ROS ...
Ying Wan, Hui Liu, Lin Gao, Guanyu Tan, Kailin Li, Qiwei Tian, Shiping Yang, Lu An   +7 more
wiley   +1 more source

The Impact of Goal Disturbance after Cancer on Cortisol Levels over Time and the Moderating Role of COMT. [PDF]

PLoS ONE, 2015
Due to physical hindrance and time spent in hospital, a cancer diagnosis can lead to disturbance of personally important goals. Goal disturbance in cancer patients has been related to poorer psychological well-being.
Moniek Janse, Martijn van Faassen, Ido Kema, Ans Smink, Adelita V Ranchor, Joke Fleer, Mirjam A G Sprangers   +6 more
doaj   +1 more source

Distribution, properties, and inhibitor sensitivity of zebrafish catechol-O-methyl transferases (COMT) [PDF]

Biochemical Pharmacology, 2017
Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is an enzyme with multiple functions in vertebrates. COMT methylates and thus inactivates catecholamine neurotransmitters and metabolizes xenobiotic catechols. Gene polymorphism rs4680 that influences the enzymatic activity of COMT affects cognition and behavior in humans.
Panula Pertti, Rozov Stanislav, Semenova Svetlana   +2 more
openaire   +3 more sources

Biosynthesis and Application of Catechins and Their Derivatives in Camellia sinensis

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This review summarizes the biosynthesis, structural diversity, and functional properties of catechins in tea. It highlights their tissue‐specific accumulation in different tea tissues and discusses the potential applications of catechin derivatives in functional foods and health‐related products.
Haiyi Yao, Yuxin Gu, Dibin Zhu, Dandan Tang, Wei Chen, Yongxian Chen, Jiaojiao Zhang, Liqiang Tan   +7 more
wiley   +1 more source

Differential Genetic and Epigenetic Regulation of Catechol-O-Methyl-Transferase (COMT) is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder

Frontiers in Behavioral Neuroscience, 2013
The catechol-O-methyltransferase (COMT) enzyme is critical for the catabolic regulation of synaptic dopamine, resulting in altered cortical functioning.
Seth Davin Norrholm, Tanja eJovanovic, Alicia eSmith, Elisabeth B Binder, Elisabeth B Binder, Torsten eKlengel, Karen eConneely, Kristina B. Mercer, Jennifer S. Davis, Kimberly eKerley, Jennifer A. Winkler, Charles F. Gillespie, Bekh eBradley, Kerry J Ressler   +13 more
doaj   +1 more source

Longitudinal Study of Treatment Variability for Parkinson's Disease across Specialized Centers

Movement Disorders Clinical Practice, Volume 12, Issue 12, Page 2207-2216, December 2025.
Abstract Background Real‐world evidence on treatment practices in Parkinson's disease (PD) has been limited due to the difficulty in collecting comprehensive and generalizable clinical data. Objectives We sought to identify treatment patterns and test how treatment changed in response to (1) falling, (2) worsening disease, and (3) worsening quality of ...
Nabila Dahodwala, Theodore Kapogiannis, Amanda Cruz, James C. Beck, Thomas L. Davis, Hongliang Liu, Sheng Luo, Anna Naito, Marilyn Neault, Miriam R. Rafferty, Adolfo Ramirez‐Zamora, Connie Marras   +11 more
wiley   +1 more source