Results 61 to 70 of about 5,625 (181)

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Adverse childhood experience referring to parental relationship is associated with the risk of alcohol dependence and with COMT Val158Met polymorphism, but out of gene-environment interactions

European Psychiatry, 2022
Introduction Gene-environment interactions (GxE) are considered to make a substantial impact on the risk of alcohol dependence (AD). Objectives The aim of the study: to test the associations between the functional polymorphism Val158Met (rs6265) in the
T. Merkulova, N. Chuprova, M. Solovieva, A. Nikolishin, A. Kibitov, S. Grechany, N. Baranok, K. Rybakova, V. Soldatkin, A. Yakovlev, A. Trusova, P. Ponizovsky, E. Krupitsky   +12 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Opicapone: A third generation COMT inhibitor

Clinical Parkinsonism & Related Disorders, 2021
Objective: To provide a drug review of the newly FDA approved catechol-O-methyl transferase (COMT) inhibitor, opicapone, for the use of end-of-motor motor fluctuation in adults with Parkinson’s disease.
Jessica Greenwood, Huy Pham, Jose Rey
doaj   +1 more source

Cobalamin‐Dependent Aryl Methyl Ether O‐Demethylases: Promising Enzymes for Biocatalytic Applications from Lignin Valorization to Organic Synthesis

ChemCatChem, Volume 17, Issue 21, November 10, 2025.
Cobalamin‐dependent aryl methyl ether O‐demethylases have high potential for biocatalytic applications, including lignin valorization and synthetic chemistry. In this review, we provide a detailed overview of such O‐demethylase systems identified to date from various microorganisms, including their mechanism, substrate scope and selectivity, and ...
Niels Krabbe Johnsen, Santipap Chaiyasarn, Zheng Guo, Jaehong Han, Bekir Engin Eser   +4 more
wiley   +1 more source

Leptin influences estrogen metabolism and increases DNA adduct formation in breast cancer cells

Cancer Biology & Medicine, 2016
Objective: The elevated incidence of obesity has been paralleled with higher risks of breast cancer. High adiposity increases leptin secretion from adipose tissue, which in turn increases cancer cell proliferation.
Samia Shouman, Mohamed Wagih, Marwa Kamel   +2 more
doaj   +1 more source

Effects of stress on catecholamine stores in central and peripheral tissues of long-term socially isolated rats

Brazilian Journal of Medical and Biological Research, 2006
Both the peripheral sympatho-adrenomedullary and central catecholaminergic systems are activated by various psycho-social and physical stressors. Catecholamine stores in the hypothalamus, hippocampus, adrenal glands, and heart auricles of long-term ...
S. Dronjak, L. Gavrilovic
doaj   +1 more source

Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test. [PDF]

PLoS ONE, 2012
Prolonged demands on the attention system can cause a decay in performance over time known as the time-on-task effect. The inter-subject differences in the rate of this decline are large, and recent efforts have been made to understand the biological ...
Julian Lim, Richard Ebstein, Chun-Yu Tse, Mikhail Monakhov, Poh San Lai, David F Dinges, Kenneth Kwok   +6 more
doaj   +1 more source

Nanoparticles Functionalized with Polymer Brushes for Gene Delivery

Advanced NanoBiomed Research, Volume 5, Issue 10, October 2025.
The engineering of the next generation gene delivery vectors requires the precise control of the architecture and physicochemical interactions controlling the transport, targeting, uptake, and release of nucleic acid materials to targeted cells. Polymer brush‐functionalized nanomaterials offer unprecedented control over such design and properties, and ...
Carlos E. Neri‐Cruz, Julien E. Gautrot
wiley   +1 more source

Multi‐Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
This review shows evidence from preclinical and clinical studies, supporting the therapeutic potential of polyphenols for diabetic kidney disease (DKD). This is due to their diverse bioactive properties and ability to intervene in intricate mechanisms of the disease.
Esienanwan E. Efiong, Emmanuel Effa, Esther Peters, Ochuko L. Erukainure, Peter U. Amadi, Joshua Onyeka Ikebuiro, Sapna Sharma, Christoph Schmaderer, Kathrin Maedler, Emmy Tuenter, Harald Grallert   +10 more
wiley   +1 more source