Results 71 to 80 of about 5,625 (181)

Dehydrodicaffeic acid dilactone, an inhibitor of catechol-O-methyl transferase.

The Journal of Antibiotics, 1976
In the screening of catechol-O-methyltransferase inhibitors, three compounds were isolated from the culture filtrate of a mushroom, Inonotus sp. One was 3,4-dihydroxycinnamic acid (caffeic acid) which had been reported as an inhibitor of this enzyme. The others were the dextrorotatory 2,6-bis-(3',4'-dihydroxyphenyl)-3,7-dioxabicyclo-[3,3,0]-octane 4,8 ...
YOSHIKI KUMADA, HIROSHI NAGANAWA, HIRONOBU IINUMA, MEIKI MATSUZAKI, TOMIO TAKEUCHI, HAMAO UMEZAWA   +5 more
openaire   +3 more sources

Comparing Parkinson's Disease Medications Categorised by Location in New South Wales, Australia: Linking the 45 and Up Study and the Pharmaceutical Benefits Scheme (PBS) Data

Australian Journal of Rural Health, Volume 33, Issue 5, October 2025.
ABSTRACT Objective Explore Parkinson's Disease (PD) related prescription patterns for people with PD living in metropolitan and non‐metropolitan areas of New South Wales, Australia. Methods Exploratory, cross‐sectional data linkage study. Participants were grouped according to geographic location and by age group: metropolitan or non‐metropolitan ...
Patricia A. Logan, Peter S. Micalos, Shanna Fealy, Marguerite Bramble, Alfred Wong   +4 more
wiley   +1 more source

Pharmacogenomics of neuropathic pain

Journal of Neuroanaesthesiology and Critical Care, 2017
Variation in pain sensitivity and analgesic drug response is well recognized among individuals. Pharmacogenomics hypothesis dictates that a patient’s response to a drug or development of adverse drug effects may depend on variation in genetic profile, in
Vandana Sharma
doaj   +1 more source

The Potential of Members of the Apple Sub‐Family Maloideae Against Obesity and Metabolic Disorders: A Review

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
The apple subfamily Maloideae includes commercially and medicinally valuable plants. The fruits and other plant parts contain antioxidant compounds, like polyphenols. When consumed, the fruit and other plant parts mostly reduce body weight in humans. Studies showed that fruits and other plant parts have an impact against obesity and metabolic disorder.
Zainab R. Abdelrahman, Mai S. Maaliah, Shtaywy S. Abdalla   +2 more
wiley   +1 more source

Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation.

PLoS ONE, 2016
Theory of mind-the ability to decode and reason about others' mental states-is a universal human skill and forms the basis of social cognition. Theory of mind accuracy is impaired in clinical conditions evidencing social impairment, including major ...
Arielle Y Zahavi, Mark A Sabbagh, Dustin Washburn, Raegan Mazurka, R Michael Bagby, John Strauss, James L Kennedy, Arun Ravindran, Kate L Harkness   +8 more
doaj   +1 more source

Biotechnological Production, Isolation and Characterisation of (2R,3S)‐2,3‐Dihydroxy‐2,3‐Dihydrobenzoate

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Several strategies for biotransformation are compared and a comprehensive analytical characterisation of the novel dihydrodiol is given. ABSTRACT Bacterial Rieske non‐heme iron oxygenases catalyse the transformation of a wide range of aromatic compounds to vicinal cis‐dihydrodiols.
Martina Kiel, Israel Barrantes, Dietmar H. Pieper, Karl‐Heinrich Engesser   +3 more
wiley   +1 more source

The CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis

The FEBS Journal, Volume 292, Issue 18, Page 4833-4853, September 2025.
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona, Giovanni Bisello, Rossella Franchini, Gianluigi Lunardi, Roberta Galavotti, Massimiliano Perduca, Rui P. Ribeiro, Benny Danilo Belviso, Alejandro Giorgetti, Rocco Caliandro, Patricia M.‐J. Lievens, Mariarita Bertoldi   +11 more
wiley   +1 more source

Pharmacogenetic guidance: individualized medicine promotes enhanced pain outcomes

Journal of Pain Research, 2017
Lisa Lynn Dragic,1 Erica L Wegrzyn,2 Michael E Schatman,3–5 Jeffrey Fudin2,6 1Central Arkansas Veterans Healthcare System, Little Rock, AR, USA; 2Department of Pharmacy, Albany Stratton VA Medical Center, Albany, NY, USA; 3Research and Network ...
Dragic LL, Wegrzyn EL, Schatman ME, Fudin J   +3 more
doaj  

Effect of pharmacological interventions on the fronto-cingulo-parietal cognitive control network in psychiatric disorders: a transdiagnostic systematic review of fMRI studies

Frontiers in Psychiatry, 2016
Executive function deficits such as working memory, decision-making, and attention problems are a common feature of several psychiatric disorders for which no satisfactory treatment exists.
Therese eVan Amelsvoort, Dennis eHernaus
doaj   +1 more source

Mouse models for preeclampsia: disruption of redox-regulated signaling

Reproductive Biology and Endocrinology, 2009
The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-O-methyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia-
Chambers Anne E, Randeva Harpal, Banerjee Subhasis   +2 more
doaj   +1 more source