Results 91 to 100 of about 27,393 (246)

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase

Molecular Pain, 2009
Background Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain.
Conrad Matthew, Wentworth Sean, Qian Li, Nackley Andrea G, Tchivileva Inna E, Diatchenko Luda B   +5 more
doaj   +1 more source

Subcutaneous Levodopa in Parkinson's Disease: A Systematic Review and Meta‐Analysis

European Journal of Neurology, Volume 33, Issue 2, February 2026.
ABSTRACT Background Many Parkinson's disease patients receiving oral levodopa/carbidopa experience a troublesome wearing off effect. Higher doses to mitigate OFF‐time are limited by adverse effects occurring at peak dopamine levels, particularly dyskinesia.
Matthew Burton, Duncan Marsden, Dhruv Harish, Peter Morris, Carl Heneghan, Ailsa Butler, David Nunan   +6 more
wiley   +1 more source

Coupling S-adenosylmethionine-dependent methylation to growth: Design and uses.

PLoS Biology, 2019
We present a selection design that couples S-adenosylmethionine-dependent methylation to growth. We demonstrate its use in improving the enzyme activities of not only N-type and O-type methyltransferases by 2-fold but also an acetyltransferase of another
Hao Luo, Anne Sofie L Hansen, Lei Yang, Konstantin Schneider, Mette Kristensen, Ulla Christensen, Hanne B Christensen, Bin Du, Emre Özdemir, Adam M Feist, Jay D Keasling, Michael K Jensen, Markus J Herrgård, Bernhard O Palsson   +13 more
doaj   +1 more source

A Systematic Approach to Identifying Protein-Ligand Binding Profiles on a Proteome Scale [PDF]

, 2008
Identification of protein-ligand interaction networks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics.
Lei Xie, Li Xie, Nancy Buchmeier, Philip Bourne   +3 more
core   +2 more sources

COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study)

Общая реаниматология, 2019
The aim: To assess the effect of COMT G1947A genetic polymorphism (val158met) on the efficacy of spinal analgesia on day 1 after laparoscopic surgery for colorectal cancer.Material and methods.
Alexander L. Potapov, Daria V. Zemskova, Tatiana I. Ivanova, Vera A. Khorokhorina, Peter V. Shegay, Sergey A. Ivanov, Andrey D. Kaprin   +6 more
doaj   +1 more source

Inhibiting microtubule polymerization with EAPB02303, a prodrug activated by catechol-O-methyl transferase, enhances paclitaxel effect in pancreatic cancer models

Cell Death and Disease
The Imiqualines family is an original group of small heterocyclic compounds, diversely substituted around different scaffolds. Among these compounds, the lead EAPB02303 displays outstanding cytotoxic activity at nanomolar concentrations comparable to ...
Kévin Bigot, Cindy Patinote, Véronique Garambois, Adrien Chouchou, Stéphanie Gayraud-Paniagua, Nadia Vie, Yann Maggipinto, Elias Smyej, Mathilde Robin, Margot Machu, Marine Bruciamacchie, Pierre-Emmanuel Colombo, Corinne Bousquet, Muriel Mathonnet, Ela Levy-Augé, Diego Tosi, Pierre-Antoine Bonnet, Céline Gongora, Carine Deleuze-Masquéfa, Christel Larbouret   +19 more
doaj   +1 more source

Association between the COMT Val158Met Genotype and Alzheimer's Disease in the Han Chinese Population

Dementia and Geriatric Cognitive Disorders Extra, 2014
Background: Alzheimer's disease (AD) is the leading cause of dementia worldwide and is associated with individual, familial and social burdens. Catechol-O-methyltransferase (COMT) may have a prominent role in AD pathophysiology by affecting the ...
Yong Ji, Zhihong Shi, Mengyuan Liu, Shuai Liu, Shuling Liu, Jinhuan Wang   +5 more
doaj   +1 more source

CATECHOLAMINE ASSAY BY RADIOENZYMATIC METHOD - A PROTOCOL

Journal of the Dow University of Health Sciences, 2008
Catecholamines are a group o f compounds identified by the catechol nucleus. The significant catecholaminesfound naturally in the body are epinephrine, nor- epinephrine and dopamine. They are found in varioustissues o f the body like brain, adrenals, GIT,
Nasim Karim, Joshua R. Berlin
doaj  

Heterosis in COMT Val158Met Polymorphism Contributes to Sex-Differences in Children’s Math Anxiety

Frontiers in Psychology, 2019
Math anxiety (MA) is a phobic reaction to math activities, potentially impairing math achievement. Higher frequency of MA in females is explainable by the interaction between genetic and environmental factors.
Annelise Júlio-Costa, Annelise Júlio-Costa, Aline Aparecida Silva Martins, Aline Aparecida Silva Martins, Guilherme Wood, Guilherme Wood, Máira Pedroso de Almeida, Máira Pedroso de Almeida, Marlene de Miranda, Marlene de Miranda, Vitor Geraldi Haase, Vitor Geraldi Haase, Vitor Geraldi Haase, Vitor Geraldi Haase, Vitor Geraldi Haase, Maria Raquel Santos Carvalho, Maria Raquel Santos Carvalho   +16 more
doaj   +1 more source