Systematic review and meta-analysis of genetic risk factors for neuropathic pain [PDF]
, 2018 Neuropathic pain (NP) is an increasingly common chronic pain state and a major health burden, affecting approximately 7-10% of the general population. Emerging evidence suggests that genetic factors could partially explain individual susceptibility to NP
Hébert, Harry L. +4 more
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Association between the COMT gene and rumination in a Hungarian sample. [PDF]
, 2016 Introduction: Rumination is a multidimensional trait which is a proven risk factor in the vulnerability to depression. The aim to identify the main risk genes for depression in addition to the gene-environment interactions pointed to the importance of
Bagdy, György +2 more
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Estrogen pathway polymorphisms in relation to primary open angle glaucoma: An analysis accounting for gender from the United States [PDF]
, 2013 Purpose Circulating estrogen levels are relevant in glaucoma phenotypic traits. We assessed the association between an estrogen metabolism single nucleotide polymorphism (SNP) panel in relation to primary open angle glaucoma (POAG), accounting for gender.
Allingham, R. Rand +34 more
core +3 more sources
Detoxication of Structurally Diverse Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones by Human Recombinant Catechol-O-methyltransferase (COMT) via O-Methylation of PAH Catechols [PDF]
, 2011 Li Zhang +6 more
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Delayed O-methylation of L-DOPA in MB-COMT-deficient mice after oral administration of L-DOPA and carbidopa [PDF]
, 2017 1.Catechol-O-methyltransferase (COMT) is involved in the O-methylation of l-DOPA, dopamine, and other catechols. The enzyme is expressed in two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-COMT), which is anchored to
Aonurm-Helm, Anu +2 more
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Dopamine, time perception, and future time perspective. [PDF]
, 2018 RationaleImpairment in time perception, a critical component of decision-making, represents a risk factor for psychiatric conditions including substance abuse.
Kayser, Andrew S +3 more
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MONOAMINE OXIDASE AND CATECHOL- O-METHYLTRANSFERASE INHIBITORS
Medical Clinics of North America, 1999 Despite advances in the treatment of PD, there remain significant unmet therapeutic needs. This is particularly true at the later stages of the disease when dopaminergic therapy is complicated by motor fluctuations and dyskinesias. Inhibition of dopamine metabolism is a valuable adjunct to exogenous dopaminergic replacement.
A, Siderowf, R, Kurlan
openaire +2 more sources
DiagnosticsStress is a ubiquitous challenge in modern societies. Symptoms range from mood swings and cognitive impairment to autonomic symptoms. This study explores the link between work-related stress and the neurobiological element of brain processing, testing ...
Saga Steinmann Madsen +6 more
doaj +1 more source
Stress‐Induced Analgesia and Morphine Responses Are Changed in Catechol‐O‐methyltransferase‐Deficient Male Mice [PDF]
, 2008 Oleg Kambur +8 more
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Enantiomers of methylenedioxy designer drugs : the role of cytochrome P450s and catechol-O-methyltransferase in their metabolism [PDF]
, 2009 In the presented studies, the CYP dependent, enantioselective N-dealkylation and demethylenation of the designer drugs MDMA (Ecstasy), MBDB (Eden), and MDEA (Eve) was investigated.
Meyer, Markus Robert
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