Results 31 to 40 of about 27,393 (246)

Sansoninto attenuates aggressive behavior and increases levels of homovanillic acid, a dopamine metabolite, in social isolation-reared mice

Journal of Traditional and Complementary Medicine, 2022
Background and aim: Early-life stress is thought to affect aggressive behavior in humans and rodents. Laboratory experiments have demonstrated that Sansoninto (SST; 酸棗仁湯 suān zǎo rén tāng), a traditional herbal medicine, attenuates stress-induced ...
Takuya Watanabe, Hikari Iba, Hiroshi Moriyama, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki   +5 more
doaj   +1 more source

Nordihydroguaiaretic Acid as a Novel Substrate and Inhibitor of Catechol O-Methyltransferase Modulates 4-Hydroxyestradiol-Induced Cyto- and Genotoxicity in MCF-7 Cells

Molecules, 2021
Nordihydroguaiaretic acid (NDGA) is a major lignan metabolite found in Larrea spp., which are widely used in South America to treat various diseases. In breast tissue, estradiol is metabolized to the catechol estrogens such as 4-hydroxyestradiol (4-OHE2),
Jin-Hee Kim, Jimin Lee, Hyesoo Jeong, Mi Seo Bang, Jin-Hyun Jeong, Minsun Chang   +5 more
doaj   +1 more source

The genomics of neonatal abstinence syndrome [PDF]

, 2017
Significant variability has been observed in the development and severity of neonatal abstinence syndrome (NAS) among neonates exposed to prenatal opioids.
Cole, F. Sessions, Davis, Jonathan M, Wegner, Daniel J   +2 more
core   +3 more sources

COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults

IBRO Reports, 2019
The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults.
Tenielle Porter, Samantha C. Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Hamid R. Sohrabi, Madeline Peretti, Yen Ying Lim, Michael Weinborn, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L. Villemagne, Simon M. Laws   +18 more
doaj   +1 more source

Catechol-O-Methyltransferase Polymorphism and Endometriosis [PDF]

Journal of Assisted Reproduction and Genetics, 2002
Catechol-O-methyltransferase (COMT) inactivates the estradiol metabolites, 2-hydroxy and 4-hydroxy catechols, which have been implicated in the pathogenesis of endometriosis. A COMT valine to methionine polymorphism (G-to-A) in exon 4 of the COMT gene is polymorphic in the human population, with 25% of Caucasians being homozygous for the low-activity ...
Fritz, Wieser, Rene, Wenzl, Clemens, Tempfer, Christoph, Worda, Johannes, Huber, Christian, Schneeberger   +5 more
openaire   +2 more sources

Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats [PDF]

, 2017
Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of catecholamines may be a critical component of the neuropathology of alcoholism.
Czachowski, Cristine L., DeLory, Michael J., Janetsian-Fritz, Sarine S., Lapish, Christopher C., McCane, Aqilah M., Timm, Maureen M.   +5 more
core   +1 more source

Hypnotizability and Catechol-O-Methyltransferase (COMT) polymorphysms in Italians

Frontiers in Human Neuroscience, 2014
Higher brain dopamine content depending on lower activity of Catechol-O-Methyltransferase (COMT) in subjects with high hypnotisability scores (highs) has been considered responsible for their attentional characteristics.
Silvano ePresciuttini, Alessandro eGialluisi, Alessandro eGialluisi, Serena eBarbuti, Michele eCurcio, Fabrizio eScatena, Giancarlo eCarli, Enrica Laura Santarcangelo   +7 more
doaj   +1 more source

Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications

Journal of Pharmaceutical Analysis, 2021
Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics that ...
Fang-Yuan Wang, Ping Wang, Dong-Fang Zhao, Frank J. Gonzalez, Yu-Fan Fan, Yang-Liu Xia, Guang-Bo Ge, Ling Yang   +7 more
doaj   +1 more source

Inhibitory Effect of Bovine Lactoferrin on Catechol-O-Methyltransferase

Molecules, 2017
Lactoferrin (LF) is a well-known multifunctional protein. In this study, we report the inhibitory potency of bovine LF (bLF) on catechol-O-methyltransferase (COMT), which catalyzes methylation of catechol substrates.
Masayuki Ikeda, Hiroshi Iijima, Ichizo Shinoda, Hiroshi Iwamoto, Yasuhiro Takeda   +4 more
doaj   +1 more source

COMT genotype and non-recovery after a whiplash injury in a Northern European population

BMC Musculoskeletal Disorders, 2017
Background The COMT (Catechol-O-Methyl Transferase) gene may influence a person’s vulnerability to develop long-term pain and some COMT single nucleotide polymorphisms (SNPs) may associate with patterns of acute or chronic pain.
Eric Rydman, Erika Comasco, H. Pettersson, L. Oreland, S. Ponzer, C. Ottosson   +5 more
doaj   +1 more source