Results 61 to 70 of about 27,393 (246)

Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review

Food Safety and Health, EarlyView.
Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra, Monika Bhadauria, Satendra Kumar Nirala   +2 more
wiley   +1 more source

Association of Catechol-O-methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients

BMC Rheumatology, 2018
Background Fibromyalgia (FM) is a complex, centralized pain condition that is often difficult to diagnose and treat. FM is considered to have a genetic background due to its familial aggregation and due to findings from multiple candidate-gene studies ...
Chee Lee, Ginevra Liptan, Svetlana Kantorovich, Maneesh Sharma, Ashley Brenton   +4 more
doaj   +1 more source

Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults [PDF]

, 2014
© 2014, The Author(s).Prefrontal dopamine levels are relatively increased in adolescence compared to adulthood. Genetic variation of COMT (COMT Val158Met) results in lower enzymatic activity and higher dopamine availability in Met carriers.
Banaschewski, T, Barker, G, Bartova, L, Berger, A, Bokde, A, Boubela, RN, Büchel, C, Conrod, P, Desrivières, S, Esterbauer, H, Flor, H, Friedrich, MH, Frouin, V, Gallinat, J, Garavan, H, Haslacher, H, Heinz, A, Huemer, J, Ittermann, B, Jia, T, Kalcher, K, Kasper, S, Lathrop, M, Martinot, JL, Meyer, BM, Moser, E, Nees, F, Perkmann, T, Pezawas, L, Popovic, A, Praschak-Rieder, N, Rabl, U, Rietschel, M, Scharinger, C, Schumann, G, Sitte, HH, Smolka, MN, Steiner, H   +37 more
core   +1 more source

Distinction and mutual Influences between Parkinson's Disease‐related and unrelated Chronic Pain

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Chronic pain (i.e. > 3 months) is a common nonmotor symptom in patients with Parkinson's disease (PD), but the attribution to PD is critical for further treatment. Objectives We explored the PD Pain Classification System (PD‐PCS) criteria for the diagnosis of PD‐related pain and mutual influences between PD‐related and PD‐unrelated ...
Jonathan Hunger, Florian Brugger, Georg Kägi, Jens Carsten Möller, Nathalie Hollenstein, David H. Benninger, Michele Tinazzi, Julien F. Bally, Roman Gonzenbach, Daniel Ciampi de Andrade, Santiago Perez Lloret, Veit Mylius   +11 more
wiley   +1 more source

Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression

Neuropsychiatric Disease and Treatment, 2021
Peiyan Ni,1– 3 Manli Liu,1– 3 Dequan Wang,1– 3 Yang Tian,1– 3 Liansheng Zhao,1– 3 Jinxue Wei,1– 3 Xueli Yu,1– 3 Xueyu Qi,1– 3 Xiaojing Li,1– 3 Hua Yu,1– 3 Rongjun Ni,1– 3 Xiaohong Ma,1 ...
Ni P, Liu M, Wang D, Tian Y, Zhao L, Wei J, Yu X, Qi X, Li X, Yu H, Ni R, Ma X, Deng W, Guo W, Wang Q, Li T   +15 more
doaj  

Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levodopa requirements in fluctuating parkinsonian patients. [PDF]

, 1997
BACKGROUND: More than 50% of patients with Parkinson's disease develop motor response fluctuations (the "wearing off" phenomenon) after more than five years of levodopa therapy.
Baas, H., Beiske, A.G., Ghika, J., Jackson, M., Oertel, W.H., Poewe, W., Ransmayr, G.   +6 more
core   +1 more source

Comparative Analysis of the Incidence, Prevalence, and Survival of 8 Types of Parkinsonism in a Population‐Based Study with 367 Million Person Years of Observation over 21 Years

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Findings are contradictory regarding changes in the incidence and prevalence of Parkinson's disease (PD) over time; data for other parkinsonian disorders are rare. Objectives To analyze temporal trends in the incidence and prevalence of eight parkinsonisms (PD, MSA, PSP, CBS, DLB, vascular parkinsonism, drug‐induced parkinsonism ...
Sacha E. Gandhi, Katherine A. Grosset, Prasanth A. Iruthayaraj, Romel Gravesande, Lance Lee, Cathal Doyle, Yoav Ben‐Shlomo, Donald G. Grosset   +7 more
wiley   +1 more source

Distribution, regulation and physiological roles of catechol-O-methyltransferase (COMT) in rodents [PDF]

, 2012
Catechol-O-methyltransferase (COMT) metabolises catecholamines such as dopamine, noradrenaline and adrenaline, which are well-characterised neurotransmitters that play important roles in the regulation of physiological processes.
Schendzielorz, Nadia
core  

Revealing quantum mechanical effects in enzyme catalysis with large-scale electronic structure simulation [PDF]

, 2018
Enzymes have evolved to facilitate challenging reactions at ambient conditions with specificity seldom matched by other catalysts. Computational modeling provides valuable insight into catalytic mechanism, and the large size of enzymes mandates multi ...
Kulik, Heather Janine, Mehmood, Rimsha, Qi, Helena Wen, Steeves, Adam H., Wang, Mengyi, Yang, Zhongyue   +5 more
core   +2 more sources

Movement Disorders Associated with 22q11.2 Microdeletion: A Scoping Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Movement disorders have recently emerged as important neurologic manifestations of the 22q11.2 microdeletion that affects nearly one in every 2000 live births. Objective We aimed to map the existing evidence regarding the spectrum, diagnosis and treatment, and etiopathogenesis of movement disorders associated with 22q11.2 ...
Nikolai Gil D. Reyes, Daniel G. Di Luca, Connie Marras, Erik Boot, Ryan K.C. Yuen, Anthony E. Lang, Anne S. Bassett   +6 more
wiley   +1 more source