Results 81 to 90 of about 27,393 (246)

Developmental changes in human dopamine neurotransmission: cortical receptors and terminators

BMC Neuroscience, 2012
Background Dopamine is integral to cognition, learning and memory, and dysfunctions of the frontal cortical dopamine system have been implicated in several developmental neuropsychiatric disorders.
Rothmond Debora A, Weickert Cynthia S, Webster Maree J   +2 more
doaj   +1 more source

Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition. [PDF]

PLoS ONE, 2018
There is evidence that altering stress mindset-the belief that stress is enhancing vs. debilitating-can change cognitive, affective and physiological responses to stress.
Alia J Crum, Modupe Akinola, Bradley P Turnwald, Ted J Kaptchuk, Kathryn T Hall   +4 more
doaj   +1 more source

Catechol-O-methyltransferase association with hemoglobin A1c [PDF]

Metabolism, 2016
Catecholamines have metabolic effects on blood pressure, insulin sensitivity and blood glucose. Genetic variation in catechol-O-methyltransferase (COMT), an enzyme that degrades catecholamines, is associated with cardiometabolic risk factors and incident cardiovascular disease (CVD).
Kathryn T. Hall, Kathleen A. Jablonski, Ling Chen, Maegan Harden, Benjamin R. Tolkin, Ted J. Kaptchuk, George A. Bray, Paul M. Ridker, Jose C. Florez, Kenneth J. Mukamal, Daniel I. Chasman   +10 more
openaire   +2 more sources

Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder : a systematic review [PDF]

, 2018
Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with high heritability rates. The contribution of genetic factors to the etiology of these disorders is increasingly being recognized as the action of multiple risk ...
Frydecka, Dorota, Gawęda, Łukasz, Misiak, Błażej, Mustafa, Ahmed A, Prochwicz, Katarzyna, Stramecki, Filip, Sąsiadek, Maria M   +6 more
core  

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect

Journal of Child Psychology and Psychiatry, EarlyView.
Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions.
Hanna C. Gustafsson, Hanna R. Wright, Jorden E. Jacinto Schreeder, Joel T. Nigg, Elinor L. Sullivan   +4 more
wiley   +1 more source

Development of fed-batch profiles for efficient biosynthesis of catechol-O-methyltransferase

Biotechnology Reports, 2014
Catechol-O-methyltransferase (COMT, EC 2.1.1.6) plays a crucial role in dopamine metabolism which has intimately linked this enzyme to some neurodegenerative diseases, such as Parkinson's disease.
G.M. Espírito Santo, A.Q. Pedro, D. Oppolzer, M.J. Bonifácio, J.A. Queiroz, F. Silva, L.A. Passarinha   +6 more
doaj   +1 more source

Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes [PDF]

, 2014
OBJECTIVE: To test whether the association between childhood abuse, cannabis use and psychotic experiences (PEs) was moderated by the COMT (catechol-O-methyltransferase) gene.
Alemany, Silvia, Arias, Barbara, Fatjó-Vilas, Mar, Fañanás Saura, Lourdes, Gastó, Cristóbal, Ibáñez, Manuel I, Moya-Higueras, Jorge, Ortet, Generós, Villa Martín, Elena   +8 more
core   +1 more source

Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men

Behavioral and Brain Functions, 2017
Background Although some effects of gene–gene interactions on nicotine–dopamine metabolism for smoking behavior have been reported, polymorphisms of cytochrome P450 (CYP) 2A6 and catechol-O-methyltransferase (COMT) have not been studied together to ...
Wei-Chih Ou, Yi-Chin Huang, Chih-Ling Huang, Min-Hsuan Lin, Yi-Chun Chen, Yi-Ju Chen, Chen-Nu Liu, Mei-Chih Chen, Ching-Shan Huang, Pei-Lain Chen   +9 more
doaj   +1 more source

Multi‐Omics Analyses Reveal the Red and Far‐Red Light Combination Enhancing Heterologous Protein and Metabolite Production in Nicotiana benthamiana

Plant, Cell &Environment, EarlyView.
ABSTRACT Transient expression of exogenous protein in Nicotiana benthamiana leaves via agroinfiltration offers a rapid and efficient platform for functional gene discovery and heterologous production of valuable eukaryotic proteins and metabolites. Though light quality is an important factor for plant photomorphogenesis, its impact on the efficiency of
Yating Zhang, Fengjiao Wang, Ran Du, Tao Li, Shaoqun Zhou, Jianbin Yan, Wei Li   +6 more
wiley   +1 more source