Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
Advanced Science, EarlyView.Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang +6 more
wiley +1 more source
One‐Pot Incorporation of Quantum Defects into Single‐Walled Carbon Nanotubes with Arylazo Sulfonates
Angewandte Chemie, EarlyView.We present a photochemical strategy to create complex aromatic quantum defects in carbon nanotubes using arylazo sulfonates. It provides access to brighter carbon nanotubes without purification and simpler biofunctionalization. Abstract Single‐walled carbon nanotubes (SWCNTs) consist of a carbon monolayer and fluoresce in the near‐infrared (NIR, 800 ...
Valeriia D. Andreeva +4 more
wiley +2 more sources
PRE-SLAUGHTER STRESS ESTIMATION BY FOURIER TRANSFORM INFRARED SPECTROSCOPY ANALYSIS
Journal of the Indonesian Tropical Animal Agriculture, 2015 The objective of the study was to analyze the potential of fourier transform infrared (FTIR) asstress estimation instrument through measurement of catecholamine (CA) and cortisol (CO) levels byinvasive and non-invasive methods.
S. Widiyanto +3 more
doaj +1 more source
Millimolar concentrations of free magnesium enhance exocytosis from permeabilized rat pheochromocytoma (PC 12) cells [PDF]
, 1989 The role of Mg2+ during the final steps of exocytosis was investigated using rat pheochromocytoma cells (PC12) permeabilized with bacterial pore forming toxins.
Ahnert-Hilger +17 more
core +1 more source
Advanced Science, EarlyView.This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li +11 more
wiley +1 more source
Effect of posterior hypothalamic knife cuts on the baroreflex and hemorrhage-induced hormonal responses. [PDF]
, 1990 We made posterior hypothalamic knife cuts in rats to transect the fibers of the medial forebrain bundle (MFB) at the level of the mammillary body. The role of the MFB in the baroreflex and hemorrhage-induced hormonal responses was then examined in the ...
Hashimoto, Kozo +2 more
core +1 more source
Advanced Science, EarlyView.Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang +12 more
wiley +1 more source
Physiological and Biochemical Effects of Echium Amoenum Extract on Mn2+-Imposed Parkinson Like Disorder in Rats [PDF]
Advanced Pharmaceutical Bulletin, 2018 Purpose: Manganism is a cognitive disorder take places in peoples are exposed to environmental manganese pollution. Overexposure to manganese ion (Mn2+) mainly influences central nervous system and causes symptoms that increase possibility of hippocampal
Leila Sadeghi +2 more
doaj +1 more source
Current Sample Preparation Methodologies for Determination of Catecholamines and Their Metabolites [PDF]
, 2022 Nian Shi +8 more
openalex +1 more source
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]
, 2015 The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam +16 more
core +2 more sources