Results 71 to 80 of about 160,740 (281)

The dopaminergic system and Alzheimer’s disease

Neural Regeneration Research
Alzheimer’s disease is a common neurodegenerative disorder in older adults. Despite its prevalence, its pathogenesis remains unclear. In addition to the most widely accepted causes, which include excessive amyloid-beta aggregation, tau ...
Yuhan Zhang, Yuan Liang, Yixue Gu
doaj   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Differential Effects of Acute Treatment With Antipsychotic Drugs on Peripheral Catecholamines

Frontiers in Psychiatry, 2020
Antipsychotic drugs represent the most effective treatment for chronic psychotic disorders. The newer second generation drugs offer the advantage of fewer neurological side-effects compared to prior drugs, but many cause serious metabolic side-effects ...
Heidi N. Boyda, Amanzo A. Ho, Lurdes Tse, Ric M. Procyshyn, Jessica W. Y. Yuen, David D. Kim, William G. Honer, Alasdair M. Barr   +7 more
doaj   +1 more source

An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon‐like peptide‐1 and glucagon receptor in healthy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Glucagon‐like peptide‐1 (GLP‐1) and glucagon dual receptor agonists are in clinical development for a range of metabolic conditions, including type 2 diabetes and obesity. The cardiovascular actions at these receptors are well studied, but less is known about their combination.
James Goodman, Victoria E. Parker, Carmel M. McEniery, Giovanni Di Stefano, Annette Hubsch, Evangelia Vamvaka, Jo Helmy, Fotini Kaloyirou, Navazh Jalaludeen, Peter Barker, Lutz Jermutus, Joseph Cheriyan, Philip Ambery, Ian B. Wilkinson   +13 more
wiley   +1 more source

A novel biomarker renalase and its relationship with its substrates in schizophrenia [PDF]

Journal of Medical Biochemistry, 2019
Background: Schizophrenia, particularly the form related to excessive dopamine (DA), is a chronic psychotic disorder affecting millions of people worldwide. Renalase metabolizes its catecholamine (CA) substrates, including DA, suggesting that there might
Catak Zekiye, Kocdemir Esra, Ugur Kader, Yardim Meltem, Sahin İbrahim, Kaya Hilal, Suleyman Aydin   +6 more
doaj  

Functional selectivity of GPCR-directed drug action through location bias. [PDF]

, 2017
G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco, Huang, Bo, Irannejad, Roshanak, Mika, Delphine, Pessino, Veronica, von Zastrow, Mark, Wedegaertner, Philip B.   +6 more
core   +3 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Hypoxic regulation of ion channel function and expression [PDF]

, 2002
Acute hypoxia regulates the activity of specific ion channels in a rapid and reversible manner. Such effects underlie appropriate cellular responses to hypoxia which are designed to initiate cardiorespiratory reflexes and contribute importantly to other ...
Peers, C.
core   +1 more source

Inhibition by Selenium Compounds of Catecholamine Secretion Due to Inhibition of Ca2+ Influx in Cultured Bovine Adrenal Chromaffin Cells

Journal of Pharmacological Sciences, 2006
.: Selenium is an essential trace metal element, whereas large doses of selenium exert adverse effects to the human body. We examined the effects of selenium compounds, sodium selenite (Na2SeO3) and sodium selenate (Na2SeO4), on catecholamine secretion ...
Uezono Yasuhito, Toyohira Yumiko, Yanagihara Nobuyuki, Wada Akihiko, Taniyama Kohtaro   +4 more
doaj   +1 more source

A proposed role for sepsis in the pathogenesis of myocardial calcification [PDF]

, 2017
Myocardial calcification is a rare and life-threatening condition that is a recognised complication of ischaemic heart disease, cardiac surgery, rheumatic fever and myocarditis.
AROMATARIO, MARIAROSARIA, Ashrafian, Hutan, Athanasiou, Thanos, Bower, Guy, CAPPELLETTI, SIMONE, CIALLELLA, Costantino, Harling, Leanne, Lee, Liang Mei   +7 more
core   +1 more source