Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background The effects of phosphodiesterase 5 (PDE5) inhibitors on the incidence of long‐term outcomes in patients with cardiovascular disease are not well understood. Objective: We studied the association between PDE5 inhibitor therapy and the incidence of adverse cardiovascular major adverse cardiovascular events (MACE) in patients ...
Sumon Roy +5 more
wiley +1 more source
Organic Cation Transporter 3: A Cellular Mechanism Underlying Rapid, Non-Genomic Glucocorticoid Regulation of Monoaminergic Neurotransmission, Physiology, and Behavior [PDF]
, 2018 Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses.
Gasser, Paul J., Lowry, Christopher A.
core +2 more sources
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background There is little data questioning the timing of intra‐aortic balloon pump (IABP) implantation in non‐cardiogenic shock patients undergoing high‐risk percutaneous procedures. Aims We compared prophylactic IABP (P‐IABP) implantation to an emergent, unplanned rescue use (R‐IABP) in high‐risk PCI. Methods Among 300 IAPB patients who were
Sascha d'Almeida +8 more
wiley +1 more source
Adjuvant pharmacological strategies for the musculoskeletal system during long‐term space missions
British Journal of Clinical Pharmacology, EarlyView., 2023 Abstract Despite 2 h of daily exercise training, muscle wasting and bone loss are still present after 6‐month missions to the international space station. Some crew members lose bone much faster than others. In preparation for missions to the Moon and Mars, space agencies are therefore reviewing their countermeasure portfolios.
Friederike Thomasius +2 more
wiley +1 more source
Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor. [PDF]
, 2019 Neuromodulation plays a critical role in brain function in both health and disease, and new tools that capture neuromodulation with high spatial and temporal resolution are needed.
Beyene, Abraham G +11 more
core +1 more source
Ascorbic acid: A useful reductant to avoid oxidation of catecholamines in electrophysiological experiments in vitro? [PDF]
, 1990 The actions of the reductant ascorbic acid on rat neocortical neurons in vitro was investigated by means of intracellular recordings. At a concentration (500 μM), which reduced the magnitude of dopamine degradation in oxygen-saturated saline solutions by
Sutor, Bernd, Ten Bruggencate, Gerrit
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Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions
Cancer Nexus, EarlyView.ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley +1 more source
The content of catecholamines in the adrenal glands and sections of the brain under hypokinesia and injection of some neurotropic agents [PDF]
The dynamics of catecholamine content were studied in the adrenal glands and in various region of the brain of white rats under hypokinesia and injections of neurotropic agents.
Melnik, B. E., Paladiy, E. S.
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Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis
ESC Heart Failure, EarlyView.Abstract COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis.
Nicolas Hulscher +3 more
wiley +1 more source
Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy
ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo +7 more
wiley +1 more source