Results 181 to 190 of about 305,262 (317)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Music is a distinct perceptual category with subjective grounds. [PDF]

Sci Rep
Larrouy-Maestri P, Aydin TA, Wald-Fuhrmann M.   +2 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

When clinical intuition fails: exploration of clinicians' underrecognition of preoperative pain catastrophizing despite direct observation. [PDF]

Pain Med
Chen YK, Wilson JM, Gokul SR, Collins PW, Kiik M, Rosado E, Vlassakov KV, Schreiber KL.   +7 more
europepmc   +1 more source

Towards tagging and categorization for micro-blogs

, 2010
Paper presented at the 21st National Conference on Artificial Intelligence and Cognitive Science (AICS 2010), Galway, Ireland, 30 August - 1 September, 2010Abstract. Micro-blogging services are becoming very popular among users who want to share local or
Garcia Esparza, Sandra, O'Mahony, Michael P., Smyth, Barry   +2 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Neural correlates of categorization uncertainty: evidence from a category induction task. [PDF]

Front Psychol
Cai X, Zhang M, Chen Z, Wu M, Tang H, Lei J, Lei M, Mao Y, Wang Y.   +8 more
europepmc   +1 more source

Text Categorization and Machine Learning Methods: Current State Of The Art

, 2012
In this informative age, we find many documents are available in digital forms which need classification of the text. For solving this major problem present researchers focused on machine learning techniques: a general inductive process automatically ...
Durga Bhavani Dasari, Dr. Venu Gopala Rao. K   +1 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Categorization of and Adaptation to Human Voice and Musical Instruments: A Passive Listening EEG Study. [PDF]

J Cogn Neurosci
Gao Z, Oxenham AJ.
europepmc   +1 more source