Results 131 to 140 of about 2,690,760 (318)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Critique and System: Early and Late Natorp’s Philosophy
RUDN Journal of PhilosophyThis paper presents an interpretation of the connection between Natorp’s early and late philosophy. An analysis of two versions of Natorp’s deduction of categories shows the consistent development of Natorp’s thought.
Hernán Pringe
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Applied Categorical Structures, 2015 We define the notion of duality categories as generalization of duality groups. Two examples are treated. The first is the Serre duality in the categories of strict polynomial functors. The second concerns finite complexes. We show in particular that finite Tits buildings are duality categories.
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Category captain arrangements in grocery retail marketing
, 2015 Purpose: The purpose of this article is to examine shelf management practices of grocery retail chains and their category captains in the marketing of consumer packaged goods.
Gururajan, Raj +2 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
[1988] Proceedings. Third Annual Information Symposium on Logic in Computer Science, 1989 A categorical generalisation of the notion of domain, used in denotational semantics, is proposed. The generalized domain is a category of ``structures'' and embeddings which is closed under directed colimits and such that any ``structure'' is the directed colimit of its finite substructures.
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交大法學評論There are significant concerns regarding the legitimacy of biometric data processing within the European Union. Therefore, it is imperative that facial data processing adheres to the criteria and standards outlined in the General Data Protection ...
Daria Bulgakova , Valentyna Bulgakova
doaj