Results 151 to 160 of about 2,690,760 (318)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Guidance for Product Category Rule Development
, 2013 This guidance document is a response to an internationally recognized need for additional instruction on the development of rules specific to a category of products for making claims based on a life cycle assessment (LCA).
IMBEAULT-TETREAULT Hugues +15 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A category of quantum categories
Theory and Applications of Categories, 2011 Quantum categories were introduced in [4] as generalizations of both bi(co)algebroids and small categories. We clarify details of that work. In particular, we show explicitly how the monadic definition of a quantum category unpacks to a set of axioms close to the definitions of a bialgebroid in the Hopf algebraic literature.
openaire +3 more sources
Probability via Expectation Measures
EntropySince the seminal work of Kolmogorov, probability theory has been based on measure theory, where the central components are so-called probability measures, defined as measures with total mass equal to 1.
Peter Harremoës
doaj +1 more source
, 2010 Probabilistic category learning (PCL) has become an increasingly popular paradigm to study the brain bases of learning and memory. It has been argued that PCL relies on procedural habit learning, which is impaired in Parkinson's disease (PD). However, as
Lagnado, DA +4 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Restriction Category Perspectives of Partial Computation and Geometry
, 2017 This thesis introduces several structures based on Cockett and Lack’s restriction categories which find applications in partial computation, geometry, topology and two-dimensional category theory.
DeWolf, Darien
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