Results 241 to 250 of about 2,690,760 (318)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Deep learning-based Breast Imaging Reporting and Data System classification and establishment of diagnostic model in breast cancer diagnosis with automated breast ultrasound. [PDF]

Quant Imaging Med Surg
Zhou X, Xu M, Luo G, Liang X, Yang F, Li B, Sun S, Liang X, Peng W, Liu Z, Li Y, Cheng W, Wang Q.   +12 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

True Preoperative Liquid Fasting in Romania-A Secondary Analysis of the Thirst Study. [PDF]

Nutrients
Moisa E, Negoita SI, Camilleri Podesta AM, Ionescu D, Tomescu DR, Mirea LE, Droc G, Grigorescu BL, Petrisor C, Drăgoescu AN, Novac MB, Ristescu AI, Blaj M, Orban C, Bedreag O, Tănase NV, Dutu M, Vintila BI, Tuculeanu G, Bilotta F, Corneci D, On Behalf Of The Romanian Thirst Study Group.   +21 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Divergent modes of episodic organization underlie whether emotional learning enhances memory across event boundaries. [PDF]

Psychon Bull Rev
Baczkowski BM, Sakaki M, Kalbe F, Murayama K, Schwabe L.   +4 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Preparatory phase of large earthquakes illuminated by unsupervised categorization of earthquake catalog features. [PDF]

Nat Commun
Karimpouli S, Martínez-Garzón P, Núñez-Jara S, Picozzi M, Spallarossa D, Kwiatek G, Dresen G, Bohnhoff M, Beroza GC.   +8 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Between Help and Harm: An Evaluation Study of Mental Health Crisis Handling by Large Language Models. [PDF]

JMIR Ment Health
Arnaiz-Rodriguez A, Baidal M, Derner E, Annable JL, Ball M, Ince M, Perez Vallejos E, Oliver N.   +7 more
europepmc   +1 more source