Results 221 to 230 of about 169,753,816 (340)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Three-Dimensional Surface Topography for Entropy-Based Comparison of Sagittal Postural Classifications in Children. [PDF]

Sensors (Basel)
Wilczyński J, Gawlik M, Bieniek K, Szumilas P, Habik-Tatarowska N, Markowski K, Świetlak W, Michalska A.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Artificial intelligence-assisted digital thyroid FNA cytology: Improved agreement and sensitivity for higher-risk Bethesda categories with enhanced screening efficiency. [PDF]

Cancer Cytopathol
Satturwar S, Li Z, Yang CS, Lin YJ, Yang WL, Lin MY, Yeh CH, Hsu SW, Liu YS, Shao G, Liu TJ, Chen CJ, Crothers BA.   +12 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Insight into Essential and Complex Autism Spectrum Disorders: Clinical Characteristics, Chromosomal Microarray Analysis, and Risk Factors. [PDF]

Genes (Basel)
Tüysüz B, Çifçi Sunamak E, Durcan G, Öztürk B, Uludağ Alkaya D, Çulpan HC, Korkmaz MB, Doğangün B, Kıykım E.   +8 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Preference assessment and reinforcer effectiveness in domestic cats. [PDF]

J Exp Anal Behav
Machado MA, Huber H, Thompson S, Monasky CA, Najafighabouri M, Cicchillo BM.   +5 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Inborn Errors of Immunity Genotype: A Retrospective Study from the United Arab Emirates. [PDF]

J Clin Immunol
Almarzooqi F, Ahmed M, Sabt MM, Aljanaahi FA, Alblooshi H.   +4 more
europepmc   +1 more source