Results 91 to 100 of about 1,977,169 (247)
American Journal of Preventive CardiologyObjective: Obesity is a chronic disease that results in increased morbidity and mortality if left untreated. Tirzepatide is a glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist approved in the United States for the ...
Naveed Sattar +8 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Challenging the role of implicit processes in probabilistic category learning [PDF]
, 2007 Considerable interest in the hypothesis that different cognitive tasks recruit qualitatively distinct processing systems has led to the proposal of separate explicit (declarative) and implicit (procedural) systems.
Lagnado, DA, Shanks, DR, Newell, BR
core
Types of category shift in the English-to-Indonesian subtitle of 'Turning red' [PDF]
, 2022 Translation has been the key to solving the problem of communicating in different languages. There are few methods used in translation, one of them is Translation Shift.
Pramesti, Safira Titah
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Shift work: An occupational health and safety hazard [PDF]
, 2003 Shift work is a major feature of modern work practices. It involves individuals working at times considered unconventional for most workers, such as at night.
Buxton, Sandra
core
Rigidity and exotic models for the K-local stable homotopy category [PDF]
, 2007 Can the model structure of a stable model category be recovered from the triangulated structure of its homotopy category? This paper introduces a new positive example for this, namely the K-local stable homotopy at the prime 2.
Roitzheim, C., Roitzheim, Constanze
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Similarity and dissimilarity as evidence in perceptual categorization [PDF]
In exemplar models the similarities between a new stimulus and each category exemplar constitute positive evidence for category membership. In contrast, other models assume that, if the new stimulus is sufficiently dissimilar to a category member, then ...
Stewart, Neil, Brown, G. D. A.
core +1 more source