Results 121 to 130 of about 1,977,169 (247)
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Physical Review Physics Education Research, 2019 In the present theoretical study, we introduce the entropy concept into Chi’s ontological shift theory. Chi distinguishes between two categories of process phenomena, direct and emergent, and claims that incorrectly considering emergent processes as ...
Alexander Volfson +2 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Night shift working pattern per serum vitamin D category.
Night shift working pattern per serum vitamin D category.
Angukumar Thangamuthu (18388000) +7 more
core +1 more source
PSYCHOLOGICAL ASSESSMENT OF EXTREMIST TEXTS: THEORETICAL ASPECTS
Теория и практика судебной экспертизы, 2014 The paper argues for a need to shift the emphasis from text to person when assessing suspected extremist materials. It examines theoretical rationale behind the scope, objects and objectives of psychological assessment in this category of integrated ...
D. Berdnikov
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Therapeutic Advances in Neurological DisordersBackground: Early use of high-efficacy therapies (EHT) in multiple sclerosis (MS) is a promising but novel treatment strategy. Its adoption in Germany’s MS care warrants further research.
Ann-Sophie Stratil +4 more
doaj +1 more source
Domain-Adaptive Underwater Target Detection Method Based on GPA + CBAM
水下无人系统学报Underwater target detection is often more susceptible to domain shift and reduced detection accuracy. In response to this phenomenon, this article proposed a domain-adaptive underwater target detection method based on graph-induced prototype alignment ...
Qidong LIU +4 more
doaj +1 more source