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Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate

Amino Acids, 2011
Cathelicidins comprise a family of antimicrobial peptides (AMPs) sharing a highly conserved cathelin domain, and play a central role in the innate defense against infection in most of vertebrates. But so far it has not yet been found in amphibians although a large number of other groups of AMPs have been identified.
Xue Hao, Hailong Yang, Shilong Yang
exaly   +3 more sources

The Cathelicidins - Structure, Function and Evolution

Current Protein & Peptide Science, 2005
The cathelicidin family of host defense peptides includes a group of cationic and usually amphipathic peptides that display a variety of activities related to host defense functions, among which the most acknowledged is a direct antimicrobial activity against various microbial pathogens.
TOMASINSIG L., ZANETTI, Margherita
openaire   +3 more sources

Evaluation of milk cathelicidin for detection of bovine mastitis [PDF]

open access: yesJournal of Dairy Science, 2016
Mastitis due to intramammary infection is one of the most economically relevant diseases in dairy cows, causing reductions in milk quality and quantity. Currently, mastitis monitoring is based on somatic cell count (SCC) and bacteriologic culture (BC) of
Maria Filippa Addis   +2 more
exaly   +2 more sources

Structure and Biology of Cathelicidins

2002
Cathelicidins are a recently discovered family of effector molecules in innate immunity. In the past few years, a great deal of investigations have elucidated several aspects of their biology, such as the gene structure and activation mechanism. Despite substantial progress in the field, several issues remain to be clarified, including the biological ...
ZANETTI M.   +3 more
openaire   +4 more sources

The Janus Face of Cathelicidin in Tumorigenesis

Current Medicinal Chemistry, 2014
Cathelicidin is a host defense peptide with multiple innate immunity-related functions. Recent findings indicate that cathelicidin is frequently dysregulated in human cancers where it plays a paradoxical yet dominant role in the regulation of tumor malignancy.
W K K, Wu   +10 more
openaire   +2 more sources

Defensins and cathelicidins in gastrointestinal infections

Current Opinion in Gastroenterology, 2007
To review recently published studies presenting novel and relevant information on antimicrobial peptides in gastrointestinal infections.Defensins and cathelicidins are important antimicrobial peptides expressed by the gastrointestinal epithelium. Their localization and regulation have been the focus of current research establishing the relevance of ...
Jan, Wehkamp   +2 more
openaire   +2 more sources

Cathelicidin deficiency predisposes to eczema herpeticum [PDF]

open access: yesJournal of Allergy and Clinical Immunology, 2006
The cathelicidin family of antimicrobial peptides is an integral component of the innate immune response that exhibits activity against bacterial, fungal, and viral pathogens. Eczema herpeticum (ADEH) develops in a subset of patients with atopic dermatitis (AD) because of disseminated infection with herpes simplex virus (HSV).This study investigated ...
Michael D Howell   +2 more
exaly   +3 more sources

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