Results 181 to 190 of about 24,668 (220)

Cathelicidins, essential gene-encoded mammalian antibiotics

Journal of Molecular Medicine, 2002
Cathelicidins are a class of gene-encoded antibiotics found exclusively in mammals. In vitro and in vivo studies indicate they are effector molecules of mammalian innate immunity that can provide a first line of defense against an array of micro-organisms.
Mohamed, Zaiou, Richard L, Gallo
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Defensins and cathelicidins in gastrointestinal infections

Current Opinion in Gastroenterology, 2007
To review recently published studies presenting novel and relevant information on antimicrobial peptides in gastrointestinal infections.Defensins and cathelicidins are important antimicrobial peptides expressed by the gastrointestinal epithelium. Their localization and regulation have been the focus of current research establishing the relevance of ...
Jan, Wehkamp, Jürgen, Schauber, Eduard F, Stange   +2 more
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Cathelicidins - Natures Attempt at Combinatorial Chemistry

Combinatorial Chemistry & High Throughput Screening, 2005
Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments. Aside from their antimicrobial activity, cathelicidins possess other biological properties including cytotoxic activity towards mammalian cells.
Ole E, Sorensen, Niels, Borregaard
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Cathelicidins Revisited

International Journal of Systems Biology and Biomedical Technologies, 2013
Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and
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Structural and functional diversity of cathelicidins.

2017
Cathelicidins are a ubiquitous family of host defence peptides (HDPs) in vertebrate animals. Unlike other HDP families, they are defined by the common and relatively well conserved proregion rather than the mature active peptides, which are highly diverse and conform to at least five different structural groups.
TOSSI, ALESSANDRO, D'ESTE, FRANCESCA, SKERLAVAJ, BARBARA, GENNARO, RENATO   +3 more
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Sensitivity of Chlamydia suis to cathelicidin peptides

Veterinary Microbiology, 2007
Nine Chlamydia suis isolates, obtained from pigs with conjunctivitis, were molecularly characterized by ompA sequencing and their in vitro susceptibility to six cathelicidin peptides (SMAP-29, BAC-7, BMAP-27, BMAP-27, BMAP-28, PG-1, LL-37) determined in cell culture.
DONATI, MANUELA, DI FRANCESCO, ANTONIETTA, Gennaro R., Benincasa M., Magnino S., PIGNANELLI, SALVATORE, SHURDHI, ALISA, Moroni A., Mazzoni C., Merialdi G., BALDELLI, RAFFAELLA, CEVENINI, ROBERTO   +11 more
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Cathelicidins, multifunctional peptides of the innate immunity

Journal of Leukocyte Biology, 2003
AbstractCathelicidins comprise a family of mammalian proteins containing a C-terminal cationic antimicrobial domain that becomes active after being freed from the N-terminal cathelin portion of the holoprotein. Many other members of this family have been identified since the first cathelicidin sequences were reported 10 years ago.
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The Janus Face of Cathelicidin in Tumorigenesis

Current Medicinal Chemistry, 2014
Cathelicidin is a host defense peptide with multiple innate immunity-related functions. Recent findings indicate that cathelicidin is frequently dysregulated in human cancers where it plays a paradoxical yet dominant role in the regulation of tumor malignancy.
W K K, Wu, J J Y, Sung, A S L, Cheng, F K L, Chan, S S M, Ng, K F, To, X J, Wang, L, Zhang, S H, Wong, J, Yu, C H, Cho   +10 more
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Antimicrobial Peptides: Defensins and Cathelicidins

2010
1 Defensins 2 Cathelicidins 3 Concluding Remarks Keywords: antimicrobial peptides, defensins and cathelicidins; antimicrobial defense-neutrophils and polymorphonucleated neutrophilic granulocytes (PMN); defensins, large and growing family of antimicrobial peptides; variability of expression; antimicrobial mechanisms; defensin ...
Robert I. Lehrer, Tomas Ganz
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Cathelicidins positively regulate pancreatic β‐cell functions

The FASEB Journal, 2015
Cathelicidins are pleiotropic antimicrobial peptides largely described for innate antimicrobial defenses and, more recently, immunomodulation. They are shown to modulate a variety of immune or nonimmune host cell responses. However, how cathelicidins are expressed by β cells and modulate β‐cell functions under steady‐state or ...
Jia, Sun, Meng, Xu, Henrik, Ortsäter, Erik, Lundeberg, Lisa, Juntti-Berggren, Yong Q, Chen, Jesper Z, Haeggström, Gudmundur H, Gudmundsson, Julien, Diana, Birgitta, Agerberth   +9 more
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