Results 121 to 130 of about 241,722 (301)

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

Acrylamide formation is prevented by divalent cations during the Maillard reaction

, 2007
The effects of mono- and divalent cations on the formation of acrylamide were studied in a fructose-asparagine model system at 150 and 180 degrees C. At amounts equivalent to those of asparagine and fructose, added divalent cations, such as Ca2+, were ...
Senyuva, Hamide Z., Goekmen, VURAL
core   +1 more source

Distinct Cleavage Trajectories Mediated by DNA and RNA Substrate in Argonaute From Methanocaldococcus Fervens

Advanced Science, EarlyView.
This study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Fuyong Huang, Taiyu Chen, Meng Fang, Qinmiao Duanmu, Kangle Mu, Yuqi Bi, Siwei Xu, Xin Tao, Jiening Wang, Shan Wu   +9 more
wiley   +1 more source

Effects of Specific Dosages of Magnesium and Zinc on the Teratogenicity of Cadmium, Nickel, and Cobalt in Embryos, as Assessed by the Fetax Test

Dose-Response, 2008
The objective of this study was to determine if exposure to divalent cations, Cd 2+ , Ni 2+ , and Co 2+ would lead to malformations in Xenopus laevis embryos, and whether addition of Mg 2+ and Zn 2+ ; separately and in combination, would reduce their ...
Ayper Boga PhD, Seref Erdogan, MD, Yasar Sertdemir PhD   +1 more
doaj   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Preparation of Lithium Carbonate from Manganese-Containing Desorption Solution from Salt Lakes via an Organophosphoric Acid Extraction System

Separations
Adsorption is a popular method for the recovery of low-grade lithium. It is a low-cost and highly efficient way to treat solutions with low lithium concentrations. The impurity content determines the industrial application.
Shaolei Xie, Yuze Zhang, Xiaowu Peng, Yong Niu, Hailong Lu, Fugen Song, Dong Shi, Lijuan Li   +7 more
doaj   +1 more source

Defect‐Engineered LiYO2 Interlayers Enabling Fast Interfacial Li+ Transport in All‐Solid‐State Batteries

Advanced Science, EarlyView.
Defect‐engineered LiYO2 interlayers are designed through aliovalent Zn2+ and Zr4+ substitution to regulate Li+ point‐defect chemistry in Ni‐rich cathodes. Compared with Li‐excess‐type LYZnO, Li‐vacancy‐type LYZrO enables faster Li+ transport, suppresses Li6PS5Cl decomposition, lowers interfacial resistance, and mitigates polarization growth, thereby ...
Sodam Kim, Yun Seong Byeon, Jaewoo Jung, Mingyu Cho, Hyunmin Lee, Jung Ho Kim, Min‐Sik Park   +6 more
wiley   +1 more source

Mode of action of calcimycin (A 23187). VI. Complexation of transition and heavy metal divalent cations in methanol

, 1993
Interaction between calcimycin HA and transition and heavy metal divalent cations M2+ in methanol was studied using potentiometry. Both MA+ and MA2 complexes are formed, except for Pb2+.
J Juillard, M Tissier, G Jeminet, A Ouahabi   +3 more
core   +1 more source

An ATP‐Driven N Protein–DDX21 Molecular Switch Dynamically Controls SARS‐CoV‐2 RNA G‐Quadruplex Heterogeneity

Advanced Science, EarlyView.
An ATP‐driven molecular switch, comprising viral nucleocapsid (N) protein and host helicase DDX21, dynamically modulates SARS‐CoV‐2 RNA G‐quadruplex (G4) heterogeneity. These viral G4s feature non‐canonical ion‐dependence and act as energy‐sensitive structural checkpoints.
Ya‐Ting Zheng, Li‐Yan Zhai, Jie Jin, Qiu‐Ying Chen, Hang Fu, Xue‐Qian Sun, Ying Lu, Hui Li, Xi‐Miao Hou   +8 more
wiley   +1 more source