Results 111 to 120 of about 2,211,448 (395)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Dynamic mortality prediction in critically Ill children during interhospital transports to PICUs using explainable AI

npj Digital Medicine
Critically ill children who require inter-hospital transfers to paediatric intensive care units are sicker than other admissions and have higher mortality rates. Current transport practice primarily relies on early clinical assessments within the initial
Zhiqiang Huo, John Booth, Thomas Monks, Philip Knight, Liam Watson, Mark Peters, Christina Pagel, Padmanabhan Ramnarayan, Kezhi Li   +8 more
doaj   +1 more source

Physical and Behavioral Measures that Predict Cats' Socialization in an Animal Shelter Environment during a Three-Day Period [PDF]

, 2013
Information from surveys completed by the cats' caregivers provided a score for the level of socialization of cats. We examined the effectiveness of structured assessments and measures in their ability to distinguish More and Less Socialized cats in a ...
Katherine Miller, Laurie Garrison, Margaret Slater   +2 more
core  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Evaluation of facial expression in acute pain in cats.

Journal of Small Animal Practice, 2014
OBJECTIVES To describe the development of a facial expression tool differentiating pain-free cats from those in acute pain. METHODS Observers shown facial images from painful and pain-free cats were asked to identify if they were in pain or not.
E. Holden, Guillermo A. Calvo, M. Collins, Andrew M. Bell, J. Reid, E. Scott, Andrea M. Nolan   +6 more
semanticscholar   +1 more source

The Dragon Reaches the Eastern Mediterranean: Why the Region Matters to China

Comparative Southeast European Studies, 2022
The Eastern Mediterranean region has been the subject of global power competition for many decades. Europe, Russia, and the United States have at different stages and in changing configurations sought to exercise influence in and power over various ...
Bastian Jens
doaj   +1 more source

Blood Pressure Measurements in 780 Apparently Healthy Cats [PDF]

, 2017
BACKGROUND: Mean systolic blood pressure in apparently healthy cats has been reported as approximately 125 mmHg using direct assessment, but there is greater variability in reported values using indirect assessment.
Ash, Belew, Bijsmans, Binns, Bodey, Bodey, Bradshaw, Brown, Brown, Brown, Caulkett, Chetboul, Cunha, Daskalopoulou, Davy, Dolores Herrera, German, Gupta, Jacob, Kobayashi, Laflamme, Lin, Maggio, Mishina, Nelson, O'Neill, Payne, Reynolds, Sansom, Smulyan, Sparkes, Syme, Wimpole   +32 more
core   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Integrating Trap-Neuter-Return Campaigns Into a Social Framework: Developing Long-Term Positive Behavior Change Toward Unowned Cats in Urban Areas

Frontiers in Veterinary Science, 2018
Cat management is often discussed in terms of population reduction, with trap-neuter-return (TNR) campaigns commonly organized to manage unowned urban cat populations.
Jennifer L. McDonald, Jennifer L. McDonald, Mark J. Farnworth, Jane Clements   +3 more
doaj   +1 more source

Gonadotropin-Releasing Hormone (GnRH) Agonist Implants for Male Dog Fertility Suppression: A Review of Mode of Action, Efficacy, Safety, and Uses

Frontiers in Veterinary Science, 2020
At present, only surgical sterilization is available for veterinarians and pet owners seeking suppression of fertility in male dogs, in most countries.
Marc Antoine Driancourt, Joyce R. Briggs
doaj   +1 more source