Results 81 to 90 of about 257,706 (312)

Protective Immunity against Infection with Mycoplasma haemofelis [PDF]

, 2015
Hemoplasmas are potentially zoonotic mycoplasmal pathogens, which are not consistently cleared by antibiotic therapy. Mycoplasma haemofelis is the most pathogenic feline hemoplasma species.
Novacco, Marilisa, Hicks, Chelsea A E, Helps, Christopher R., Hofmann-Lehmann, Regina, Stokes, Christopher R., Tasker, Séverine, Riond, Barbara, Willi, Barbara, Meli, Marina L.   +8 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Mind the gap: A comparative study of low-car policy acceptance

European Transport Studies
The introduction or even consideration of low-car interventions may spark a heated debate amongst residents as well as between local authorities and residents.
Anastasia Roukouni, Oded Cats
doaj   +1 more source

Observations on the Development of Echinococcus multilocularis in Cats

, 2003
The development of a European isolate of Echinococcus multilocularis was compared in cats and dogs at the end of the prepatent period. Echinococcus multilocularis established in all dogs and cats, but worm recovery was significantly greater from dogs ...
Deplazes, P., Thompson, R.C.A., Eckert, J.   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Roaming habits of pet cats on the suburban fringe in Perth, Western Australia: What size buffer zone is needed to protect wildlife in reserves?

, 2008
We radiotracked 18 pet cats Felis catus from rural and urban areas within the City of Armadale, Western Australia, both at night and during the day between August 2003 and February 2005 to estimate the size of buffer zone required to reduce incursions by
Calver, M.C., Garkaklis, M.J., Lilith, M.   +2 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Multi-modal and multi-layer robustness analysis of the European rail and air networks

Scientific Reports
The robustness of long-distance transport services is paramount for ensuring network connectivity under disruptions. We conduct a comparative analysis of the European rail and air networks of 124 main metropolitan areas, assessing their ability to ...
Nicola Ippolito, Oded Cats
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Topological assessment of recoverability in public transport networks

Communications Physics
Reducing the impact of disruptions is essential to provide reliable and attractive public transport. In this work, we introduce a topological approach for evaluating recoverability, i.e., the ability of public transport networks to return to their ...
Renzo Massobrio, Oded Cats
doaj   +1 more source