Results 71 to 80 of about 605,224 (307)

Domestic cat management in the UK: learnings from a global perspective

Frontiers in Veterinary Science
The overpopulation of domestic cats has the potential to result in negative outcomes for cats, people and the surrounding environment. A whole-population approach to management requires a system of services considering owned, shelter and free-living ...
Jenni L. McDonald, Dave J. Hodgson, Claire Roberts, Lauren Finka, Vicky Halls, Rae Foreman-Worsley   +5 more
doaj   +1 more source

A liver core needle biopsy technique in guinea pigs (Cavia porcellus)

Acta Veterinaria Scandinavica, 2019
The aim of this study was to describe a core needle biopsy technique in the guinea pig (Cavia porcellus) and to assess the incidence of complications when applying this method.
Kamila Glińska-Suchocka, Marcin Jankowski, Krzysztof Kubiak, Jolanta Spużak, Pola Borusewicz, Dominika Kubiak-Nowak   +5 more
doaj   +1 more source

Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats [PDF]

, 2016
The objective of this study was to model the pharmacokinetics (PKs) of robenacoxib in cats using a nonlinear mixed‐effects (NLME) approach, leveraging all available information collected from cats receiving robenacoxib s.c.
Beal, Benet, Dziak, Fink, Giraudel, Jung, King, Lainesse, Lascelles, Lavielle, Lavielle, Lees, Lehr, Martin-Jiménez, Mochel, Mochel, Pelligand, Pelligand, Savic, Sheiner, Sheiner, Sheiner, Silber, Thomasy, Toutain, Toutain, Toutain, Xu   +27 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Social challenges of spatial planning for outdoor cat management in Amami Oshima Island, Japan [PDF]

, 2017
Outdoor cats pose substantial threats to native biodiversity, especially on islands. However, cats also provide benefits to people, such as companionship and the killing of pests.
Kubo, Takahiro, Mameno, Kota, Suzuki, Mariko   +2 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Searching for ivermectin resistance in a Strongylidae population of horses stabled in Poland

BMC Veterinary Research, 2017
Background There are no available studies describing the possible resistance of strongyles to ivermectin in horses in Poland. One hundred seventy three horses from nine stud farms from South-Western Poland were studied.
A. Zak, N. Siwinska, M. Slowikowska, H. Borowicz, K. Kubiak, J. Hildebrand, M. Popiolek, A. Niedzwiedz   +7 more
doaj   +1 more source

An overview of the current genetic and phenotypical selection strategies to reduce the prevalence of feline hypertrophic cardiomyopathy = Een overzicht van de huidige genetische en fenotypische selectiestrategieën tegen hypertrofe cardiomyopathie bij de kat [PDF]

, 2020
Hypertrophic cardiomyopathy (HCM) is a common and potentially lethal heart disease in cats. To reduce its prevalence, breeding cats are frequently screened on the basis of their phenotype or genotype.
Broeckx, Bart, Peelman, Luc, Schipper, Tom, Smets, Pascale   +3 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source