Results 111 to 120 of about 537,647 (300)
Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. [PDF]
, 2017 Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach.
Asian Genetic Epidemiology Network Consortium +43 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
FAMILY KIZLYAR (KIZLYAR) REGIMENT THE CAUCASIAN LINEAR COSSACK ARMY
Гуманитарные и юридические исследования, 2021 The article studies the problems of formation and functioning of the Kizlyar regiment of the Caucasian Linear Cossack army. Based on the analysis of the published source a number of facts about Tersko-Semeyny and Tersko-Kizlyar Cossack armies on the eve ...
Nikolaj Nikolaenko
doaj
FOREIGN AND RUSSIAN CAUCASIAN STUDIES: HISTORY AND CONTEMPORARY CONDITION
Philology. Theory & Practice, 2018 In this article, which is of an overview nature, the object of scientific reflection is a series of the most significant works of the foreign and Russian specialists in Caucasian studies. Relying on them, the author reproduces the diachrony of multidimensional comprehension of the North Caucasus by travelers, ethnographers, historians, geographers ...
openaire +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
КавказологияThe article, based on analysis of the works of the promiment Georgian scientist N.A. Berdzenishvili (1894-1965), traces the influence of the ideas of M.A. Polievktov on the formation of the school of Georgian Caucasian studies. N.A.
Yuri S. Sulaberidze
doaj +1 more source
Scientific Reports, 2018 Clusterin (CLU) is considered one of the most important roles for pathogenesis of Alzheimer’s Disease (AD). The early genome-wide association studies (GWAS) identified the CLU rs11136000 polymorphism is significantly associated with AD in Caucasian ...
Zhijie Han +3 more
doaj +1 more source