Results 101 to 110 of about 539,902 (298)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Glu298Asp Endothelial Nitric Oxide Synthase Gene Polymorphism and Coronary Artery Disease in Caucasians, a Meta-Analysis [PDF]
Iranian Journal of Public Health, 2005 Objective: A number of studies recently reported a positive association between the Glu298Asp polymorphism in endothelial nitric oxide synthase gene and coronary artery diseases (CAD), however, others were unable to replicate these finding.
HR Nakhai-Pour
doaj +2 more sources
ACADEMICIAN V.V. BARTOLD AND CAUCASIAN STUDIES
History, Archeology and Ethnography of the CaucasusThe study of the Caucasus did not constitute Academician V.V. Bartold’s primary academic focus. Nevertheless, as a scholar specializing in medieval history and literature (Turkologist, Iranist, and Arabist), an Islamic scholar, and an administrator, Bartold frequently engaged with the history of the Caucasus.
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
FAMILY KIZLYAR (KIZLYAR) REGIMENT THE CAUCASIAN LINEAR COSSACK ARMY
Гуманитарные и юридические исследования, 2021 The article studies the problems of formation and functioning of the Kizlyar regiment of the Caucasian Linear Cossack army. Based on the analysis of the published source a number of facts about Tersko-Semeyny and Tersko-Kizlyar Cossack armies on the eve ...
Nikolaj Nikolaenko
doaj
FOREIGN AND RUSSIAN CAUCASIAN STUDIES: HISTORY AND CONTEMPORARY CONDITION
Philology. Theory & Practice, 2018 In this article, which is of an overview nature, the object of scientific reflection is a series of the most significant works of the foreign and Russian specialists in Caucasian studies. Relying on them, the author reproduces the diachrony of multidimensional comprehension of the North Caucasus by travelers, ethnographers, historians, geographers ...
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Immunohistochemical Expression of Matrix Metalloprotease-2 and Matrix Metalloprotease-9 in the Disks of Patients with Temporomandibular Joint Dysfunction [PDF]
, 2015 Purpose Matrix metalloproteases (MMPs) are tissue-remodeling enzymes that function during the remodeling process, such as in immune-inflammatory diseases.
Almeida, Luis Eduardo +6 more
core +1 more source