Results 81 to 90 of about 539,902 (298)

Assessing the Spatial Relationship Between Fixation and Foveal Specializations [PDF]

, 2016
Increased cone photoreceptor density, an avascular zone (FAZ), and the displacement of inner retinal neurons to form a pit are distinct features of the human fovea.
Carroll, Joseph, Cooper, Robert F., Dubis, Adam M., Dubra, Alfredo, Summerfelt, Phyllis, Wilk, Melissa A.   +5 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

FEATURES OF EUROPEAN ADAPTATION OF NORTH CAUCASIAN EMIGRANTS IN THE 1920-1930-s: PROBLEMS OF LANGUAGE AND EDUCATION

Кавказология, 2020
The aim of this article is to describe the key aspects of adaptation of North Caucasians who emigrated to Europe in the 1920-s. The author considers language problems (French, Russian and North Caucasian languages) and problems of education and training ...
I. L. BABICH
doaj   +1 more source

Amalgamated reference data for size-adjusted bone densitometry measurements in 3598 children and young adults – the ALPHABET study [PDF]

, 2016
The increasing use of dual energy X-ray absorptiometry (DXA) in children has led to the need for robust reference data for interpretation of scans in daily clinical practice.
Adams, J.E., Ahmed, S.F., ALPHABET Study Team, ., Arundel, P., Bebbington, N.A., Bishop, N.J., Crabtree, N.J., Fewtrell, M.S., Högler, W., Mughal, M.Z., Shaw, N.J., Treadgold, L.A., Ward, K.A.   +12 more
core   +5 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Comparisons of the efficacy of alpha glucosidase inhibitors on type 2 diabetes patients between Asian and Caucasian.

PLoS ONE, 2013
BackgroundTo compare the efficacy of glycemic control and insulin secretion of alpha glucosidase inhibitors (AGI) on type 2 diabetes patients between Asian and Caucasian.Methodology/principal findingsThe MEDLINE®, EMBASE®, CENTRAL were searched and ...
Xiaoling Cai, Xueyao Han, Yingying Luo, Linong Ji   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. [PDF]

, 2017
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach.
Asian Genetic Epidemiology Network Consortium, Burdon, Kathryn P, Chen, Ching J, Chen, Yii-Der Ida, Cheng, Ching-Yu, Chong, Yong He, Christiansen, Mark W, Cotch, Mary Frances, Craig, Jamie E, Fan, Qiao, Gan, Alfred, Gudnason, Vilmundur, Guo, Xiuqing, Hai, Yang, Hancock, Heather, Hanis, Craig L, Huang, Yu-Chuen, Hung, Yi-Jen, Ipp, Eli, Jensen, Richard A, Jia, Yucheng, Kaidonis, Georgia, Kim, Jihye, Klein, Barbara EK, Klein, Ronald, Kuo, Jane, Lee, Wen-Jane, Li, Xiaohui, Liao, Wen-Ling, Liew, Gerald, Mitchell, Paul, Penman, Alan, Pollack, Samuela, Price, Alkes, Psaty, Bruce M, Rotter, Jerome I, Sandow, Kevin, Smith, Albert V, Sobrin, Lucia, Stanwyck, Lynn K, Tan, Gavin, Tsai, Fuu-Jen, Wang, Jie Jin, Wong, Tien Yin   +43 more
core   +1 more source

Genetic modifiers of ambulation in the cooperative international Neuromuscular Research Group Duchenne natural history study [PDF]

, 2015
OBJECTIVE: We studied the effects of LTBP4 and SPP1 polymorphisms on age at loss of ambulation (LoA) in a multiethnic Duchenne muscular dystrophy (DMD) cohort.
Andreone, Luz, Bello, Luca, Cnaan, Avital, Cooperative International Neuromuscular Research Group Investigators, Dubrovsky, Alberto, Duong, Tina, Gordish Dressman, Heather, Henricson, Erik K., Hoffman, Eric P., Kesari, Akanchha, McDonald, Craig M., Morgenroth, Lauren P., Pegoraro, Elena, Punetha, Jaya   +13 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source