Results 61 to 70 of about 12,714,256 (245)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Jahrbuch für WirtschaftsgeschichteBy considering the expansion of the timber trade in southeast Europe as a resource frontier, this article explores the relationships between the transformation of the technical and material conditions of forest exploitation and the development of its ...
Daheur Jawad
doaj +1 more source
Frontiers in Psychology, 2015 Previous studies have reported that 3- to 4-month-olds show a visual preference for faces of the same gender as their primary caregiver (e.g., Quinn et al., 2002).
Shaoying eLiu +6 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Perspective (Institute for Christian Studies)
, 2017 Cover title: Jubilee: Where Justice and Peace EmbraceTable of Contents: Reformation and Jubilee / Kiegan Irish -- In Defence of Intellect / Joshua Harris -- "Come In, the Water's Fine" / Julia De Boer -- Christian Scholarship in Light of the Wisdom of ...
De Boer, Julia +5 more
core +3 more sources
Tense, aspect, modality and finiteness in East Caucasian languages
, 2011 Based on selected presentations given at the conference "Morphosyntax of Caucasian Languages" held in December 2006 at the Collège de France (Paris).This collection of papers deals with the morphosyntax of verbal categories in a broad sample of languages
Maisak, Timur, Authier, Gilles
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
PLoS ONE, 2013 BackgroundTo compare the efficacy of glycemic control and insulin secretion of alpha glucosidase inhibitors (AGI) on type 2 diabetes patients between Asian and Caucasian.Methodology/principal findingsThe MEDLINE®, EMBASE®, CENTRAL were searched and ...
Xiaoling Cai +3 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source