Results 111 to 120 of about 12,714,256 (245)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Laurus nobilis L. Ekstraktlarının Bazı Patojen Bakteriler Üzerindeki Antibakteriyel Etkileri ve Bileşenlerinin MreC Proteini ile Etkileşimlerinin Moleküler Kenetlenme Yöntemi ile Değerlendirilmesi

Patojen mikroorganizmaların çoklu antibiyotik direnci geliştirmesi tedavi sürelerinin uzaması, ölüm oranlarının artması ve ekonomik kayıplara neden olmaktadır.
Serkan Sugeçti, Mustafa Sertçelik
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

A meta Analysis on the Relationship between Myeloperoxidase G-463A Genetic Polymorphisms and Lung Cancer Susceptibility

Chinese Journal of Lung Cancer, 2010
Background and objective The relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility has been studied extensively. However, the outcomes are not consistent.
Qinghua ZHOU, Hongyu LIU, Shujun LI, Jundong GU, Jing WANG, Feng HUA   +5 more
doaj  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Perspective (Institute for Christian Studies)

, 2014
Errata Note: Dettloff, Dean. "Cynics in the Face of Apocalypse." Perspective 48, no. 2 (Sept 2014): 5. The first two sentences of paragraph 5 should read: To combat modern cynicism, Sloterdijk suggests returning to the figure of Diogenes, emblematic of ...
Ratzlaff, Caleb, Fernhout, Harry, Institute for Christian Studies, Dettloff, Dean, Van der Leek, Ethan, Kinsman, Daryl, Acero-Ferrer, Hector, Kirby, Joseph, Zuidervaart, Lambert, Olthuis, James H.   +9 more
core   +1 more source

Mortality in the Caucasus [PDF]

With the collapse of the Soviet Union, Caucasian countries experienced remarkable migration flows, political conflicts, and deterioration of civil registration systems.
Irina Badurashvili, Jacques Vallin, France Meslé, Géraldine Duthé, Karine Kuyumjyan   +4 more
core  

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source