Results 131 to 140 of about 543,048 (284)
Dying without Dignity: Homeless Deaths in Los Angeles County: 2000 - 2007 [PDF]
This report is an investigation into 2,815 homeless deaths in Los Angeles County between January, 2000 and May, 2007, based on statistics provided by the Los Angeles County Coroner's office.
Bob Erlenbusch +3 more
core
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Background and objective The relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility has been studied extensively. However, the outcomes are not consistent.
Qinghua ZHOU +5 more
doaj
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A case study for the institutional management of the Caucasus studies in Russian Empire
This article discusses the history of the scientific institutions functioning established in the second half of the XIX century in Caucasus to study it.
T. A. Kolosovskaya
doaj +1 more source
CAN PROMOTING CULTURAL DIVERSITY BACKFIRE? A LOOK AT THE IMPLICIT EFFECTS OF PSYCHOLOGICAL REACTANCE [PDF]
Psychological reactance occurs when an individual's freedom to engage in a particular behavior is compromised, resulting in a greater urge to engage in that behavior (Brehm, 1966).
Gruen, Jeffrey Adam
core
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source

