Results 91 to 100 of about 708,687 (281)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Advancing causal inference in ecology: Pathways for biodiversity change detection and attribution

Methods in Ecology and Evolution
Understanding the causes of biodiversity change is essential for addressing environmental challenges. While causal attribution has advanced in other fields, ecologists remain cautious about causal claims or misinterpret predictive models as causal.
Franziska Schrodt, Miriam Beck, Joaquim Estopinan, Diana E. Bowler, Colin Fontaine, Pierre Gaüzère, Romain Goury, Matthias Grenié, Inês S. Martins, Naia Morueta‐Holme, Luca Santini, Mickael Hedde, Gabrielle Martin, Emmanuelle Porcher, Sara Si‐Moussi, Marianne Tzivanopoulos, Grant Vernham, Cyrille Violle, Wilfried Thuiller   +18 more
doaj   +1 more source

Causal Learning: Monitoring Business Processes Based on Causal Structures

Entropy
Conventional methods for process monitoring often fail to capture the causal relationships that drive outcomes, making hard to distinguish causal anomalies from mere correlations in activity flows.
Fernando Montoya, Hernán Astudillo, Daniela Díaz, Esteban Berríos   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Investigating the impact of causal attributions on anorexia nervosa stigma

Journal of Eating Disorders
Background Stigmatisation of eating disorders can have debilitating consequences for individuals experiencing such conditions, such as reduced help-seeking and physical and mental deterioration. Dispositional attribution of blame appears to be central to
Rebecca Forde, Helen O’Shea
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Causal Attribution of the Interannual Variability in Flood Peaks Through Bayesian Networks

Water Resources Research
Classical regression models, due to the limited computational expense and good performance, can be used for the attribution of interannual variability in flood peaks.
J. S. Nanditha, Gabriele Villarini, Hanbeen Kim, Philippe Naveau   +3 more
doaj   +1 more source

Reproduction and genetic causal attribution of epilepsy. [PDF]

Epilepsia, 2022
Ottman R, Wetmore JB, Camarillo IA, Rodriguez S, Misiewicz S, Siegel K, Chung WK, Phelan JC, Leu CS, Yang LH, Choi H.   +10 more
europepmc   +1 more source