Results 101 to 110 of about 1,885,121 (279)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
FoodsChardonnay (Vitis vinifera L.) is one of the most widely cultivated white grape varieties in Chile, yet integrated studies addressing phenolic composition, polysaccharides, and color in commercial wines remain limited.
Alvaro Peña-Neira +5 more
doaj +1 more source
Investigating the Mediating Role of Achievement Goals in the Effect of Need Forclosure and Academic Procrastination [PDF]
رویکردهای نوین آموزشی, 2016 The aim of the present study was investigating the mediating role of achievement goals in the relationship between need for closure and academic procrastination.
A. Rastegar +3 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
On a Loophole in Causal Closure: Reply to Berber & Đorđević [PDF]
In this Reply, I explain why the “loophole view” of causal closure is independent of the reasons why the Principle of the causal closure of the physical was ...
Gamper, Johan
core +2 more sources
The End of the World? Mental Causation, Explanation and Metaphysics
Humana.Mente: Journal of Philosophical Studies, 2015 In this paper we offer some ideas on the relationship between metaphysics of causation and common explanatory practices of behaviour. We first suggest a sort of “negotiating model” for theorizing about mental causation, and then examine the so-called ...
Michele Di Francesco, Alfredo Tomasetta
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source