Results 111 to 120 of about 1,885,121 (279)

Causal closure of physics and the formulation of physicalism

Facta universitatis - series: Physics, Chemistry and Technology, 2015
Physicalism is an ontological doctrine according to which everything in the world is physical in the last instance. This is usually interpreted as a claim that every non-physical, most notably every mental property can either be reduced to some physical property or shown to supervene on it.
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Latanoprost Induced Iris Pigment Epithelial and Ciliary Body Cyst Formation in Hypermetropic Eyes

Case Reports in Ophthalmological Medicine, 2017
Purpose. Latanoprost has become one of the most widely prescribed topical antihypertensive medications in recent years. Yet there have been few reports of secondary iris pigment epithelial (IPE) and ciliary body (CB) cyst formation to date and none, to ...
Abhijit Anand Mohite, Rangarajan V. Prabhu, Thomas Ressiniotis   +2 more
doaj   +1 more source

Bidirectional Causal Relationships between Corneal Biomechanics and Glaucoma or Intraocular Pressure

Ophthalmology Science
Objective To investigate the bidirectional causal relationships between corneal biomechanics (corneal hysteresis [CH] and corneal resistance factor [CRF]) and glaucoma subtypes or intraocular pressure (IOP), and to evaluate the mediating role of IOP in ...
Xiaoyu Zhou, Jiahao Xu, Xuan-Chu Duan
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CLOSURE #2.5: Kieler e-Journal für Comicforschung [PDF]

, 2016
Auch 2016 reißt das Interesse am Medium Comic nicht ab. Die Zahl der Veröffentlichungen steigt nach wie vor an, wobei kleine Verlage zunehmend den etablierten Häusern das Feld streitig machen.

core   +1 more source

Changes of Poleward Oceanic Heat and Salt Transport Associated With the Central Eurasian Seaway During the Early Paleogene

Geophysical Research Letters
During the early Paleogene, the Arctic Ocean existed in a warm yet restricted freshwater regime, with episodic strong freshening leading to proliferation of the freshwater‐adapted Azolla at basal middle Eocene times (49–48 Ma).
Chenguang Zhu, Jian Zhang, Chenyu Zhu, Congcong Gai, Chengshan Wang   +4 more
doaj   +1 more source

A loop closure approach for humanoids navigation, An approach to the loop closure problem, robust to severe view-point changes [PDF]

, 2013
A loop closure approach for humanoids navigation with visual-inertial data.\nThe approach is robust to severe view-point changes thanks to an estimation of view-point invariant frontal views of ...
Marostica, Michele
core