Results 71 to 80 of about 23,465 (251)

Causal closure in panpsychism

Theoria, Beograd
The mind-body problem has posed the questions: can we defend mental causation, or is there causal relevance of mental qua mental over and above physical in human behaviour? This would mean that conscious experience is not a physical phenomenon, though it has causal relevance in the world.
openaire   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Closure and Complexity of Temporal Causality

2025 40th Annual ACM/IEEE Symposium on Logic in Computer Science (LICS)
Temporal causality defines what property causes some observed temporal behavior (the effect) in a given computation, based on a counterfactual analysis of similar computations. In this paper, we study its closure properties and the complexity of computing causes.
Carelli, Mishel, Finkbeiner, Bernd, Siber, Julian   +2 more
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Interpretable AI-driven causal inference to uncover the time-varying effects of PM2.5 and public health interventions on COVID-19 infection rates

Humanities & Social Sciences Communications
Although COVID-19 appears to be better controlled since its initial outbreak in 2020, it continues to threaten citizens in different communities due to the unpredictability of new strains.
Yang Han, Jacqueline C. K. Lam, Victor O. K. Li, Jon Crowcroft   +3 more
doaj   +1 more source

Causal closure of the physical, mental causation, and physics [PDF]

European Journal for Philosophy of Science, 2019
The argument from causal closure of the physical (CCP) is usually considered the most powerful argument in favor of the ontological doctrine of physicalism. Many authors, most notably Papineau, assume that CCP implies that physicalism is supported by physics.
openaire   +1 more source

Evaluation of the Causal Factors of Complications Following Ileostomy Closure

Pakistan BioMedical Journal, 2020
To estimate the causative factors of complications in ileostomy reversal. This study was conducted at the Department of Surgery Khairpur Medical College Khairpur Mirs from January 2021 to December 2021. Methods: This analysis comprised 52 patients selected consecutively who underwent ileostomy reversal within one year. The study excluded patients under
Zulfiqar Ali Shar, Zahoor Hussain, Siraj ud Din, Iftikhar Ahmed, Farman Ali, Aijaz Hussain Memon   +5 more
openaire   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source