Results 121 to 130 of about 1,964,226 (308)

Small dataset augmentation with radial basis function approximation for causal discovery using constraint-based method

ETRI Journal
Causal analysis involves analysis and discovery. We consider causal discovery, which implies learning and discovering causal structures from available data, owing to the significance of interpreting causal relationships in various fields.
Chan Young Jung, Yun Jang
doaj   +1 more source

Interpretable Knowledge Tracing via Transformer-Bayesian Hybrid Networks: Learning Temporal Dependencies and Causal Structures in Educational Data

Applied Sciences
Knowledge tracing, the computational modeling of student learning progression through sequential educational interactions, represents a critical component for adaptive learning systems and personalized education platforms.
Nhu Tam Mai, Wenyang Cao, Wenhe Liu
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Bias Injection Technique to Assess the Resilience of Causal Discovery Methods

IEEE Access
Causal discovery (CD) algorithms are increasingly applied to socially and ethically sensitive domains. However, their evaluation under realistic conditions remains challenging due to the scarcity of real-world datasets annotated with ground-truth causal ...
Martina Cinquini, Karima Makhlouf, Sami Zhioua, Catuscia Palamidessi, Riccardo Guidotti   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Causal Discovery and Classification Using Lempel–Ziv Complexity

Mathematics
Inferring causal relationships in the decision-making processes of machine learning models is essential for advancing explainable artificial intelligence.
Dhruthi, Nithin Nagaraj, Harikrishnan Nellippallil Balakrishnan   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Root Cause Attribution of Delivery Risks via Causal Discovery with Reinforcement Learning

Algorithms
Managing delivery risks is a critical challenge in modern supply chain management due to the increasing complexity and interdependencies of global supply networks.
Shi Bo, Minheng Xiao
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source